If self-directed is used in a sentence in such a way that it means "initiative and the ability to organize oneself" just like in the second sentence (If you self-direct your services, you will be guided by your co-members.), then the Tagalog translation would be sariling-kusa.

On the other hand, in your other sample phrase (Self-directed life of a man with developmental disability), self-directed was used to mean "under one's own control or direction". In this case, the suitable Tagalog translations include makapag-iisa or hindi umaasa sa iba.