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Sample translations submitted: 1
English to Turkish: VERISOL®WHITE PAPER 2014 General field: Medical Detailed field: Medical: Pharmaceuticals
Source text - English Preclinical studies
In several scientific experiments the potential of VERISOL® for skin cell metabolism and skin beauty from within was investigated.
Previous bioavailability studies demonstrated that collagen peptides could be detected in different organs and connective tissues after oral administration.
Almost 100 % of the orally applied collagen peptides are rapidly absorbed from the gastrointestinal tract as indicated by a pronounced increase of these peptides in blood plasma within first 12 hours. Later on these peptides are detectable in several organs and tissues, including the skin, in divergent amounts.
Skin is one of the predominantly accumulating organs caused by a high blood flow rate and good absorption of small collagen peptides in this tissue.
In addition to the excellent bioavailability, a positive effect of VERISOL® on skin cell metabolism could be demonstrated in several experiments.
Experimental studies on different primary human skin
cell types revealed a stimulatory effect of VERISOL® on
the biosynthesis of skin extracellular matrix macromolecules.
Treatment of epidermal skin cells (keratinocytes)
led to an up-regulation of filaggrin, loricrin and involucrin,
cornified envelope proteins which are important for
a healthy epidermal skin barrier and skin moisturizing
(data not shown).
Translation - Turkish Klinik Öncesi Araştırmalar
Birçok bilimsel deneylerdeki klinik öncesi çalışmalarda deri hücresi metabolizması ve deri güzelliğine yönelik VERISOL® potansiyeli araştırılmıştır.
Önceki biyoyararlanım çalışmaları göstermiştir ki, oral uygulamadan sonra kolajen peptitleri
farklı organlarda ve bağ dokularda tespit edilebilmektedir1.
Oral olarak alınan kolajen peptitlerin hemen hemen % 100'ü, aynen bu peptitlerin kan plazmasında ilk 12 saatte belirgin artışında olduğu gibi gastrointestinal sistemde hızlıca absorbe edilmiştir. Sonrasında bu peptitler derinin de içinde bulunduğu bazı organlarda ve dokularda değişik miktarlarda bulunabilir.
Deri, yüksek kan akış oranı ve küçük kolajen peptitlerinin yüksek absorbesi nedeniyle bu çalışmada ağırlıklı olarak birikim gerçekleşen organlardan birisidir.
Mükemmel biyoyararlanıma ek olarak, deri hücresi metabolizmasına VERISOL® 'ün pozitif bir etkisi birçok uygulamada gösterilebilir.
Değişik primer insan derisi hücre tipleri üzerine deneysel çalışmalar VERISOL® 'ün deri dışı hücreler matriks makro moleküllerin biyosentezi üzerindeki uyarıcı etkisini göstermiştir. Epidermal deri hücrelerinin (keratinositler) davranışı bir filaggrin, loricrin ve involukrini, sağlıklı bir epidermal deri duvarı ve derinin nemlenmesi için önemli olan "cornified envelope" proteinlerinin düzenlemesine yol açtı (veri sunulmamıştır).
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Years of experience: 11. Registered at ProZ.com: Jun 2018.
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