English to Russian Medical Medical: Pharmaceuticals Summary of Clinical Pharm

Another Study D1001013 evaluated the pharmacological effects on the CNS penetration of varying doses of lurasidone using quantitative electroencephalography (EEG) and the flicker test.
Study D1001013 was a randomized, double-blind, single-center, single dose per period, crossover study designed to evaluate the pharmacological effects of lurasidone 20 mg and 40 mg or matching placebo on the CNS penetration in 44 healthy Japanese adult male by quantitative EEG and the flicker test.
In the flicker test, lurasidone decreased the threshold of flicker discrimination at doses of 20 and 40 mg.
Lurasidone decreased the threshold of flicker discrimination in the flicker test without affecting the GFP value in any frequency band in quantitative EEG after single administration at doses of 20 and 40 mg.
A decrease in the threshold of flicker discrimination was noted at the lurasidone 20 mg and 40 mg dose.
Lurasidone decreased the threshold of flicker discrimination in the flicker test without affecting the GFP value in any frequency band in quantitative EEG after single administration at doses of 20 and 40 mg.
Evaluate the effect of lurasidone on CNS by EEG and flicker test and assess the safety and PK of single dose lurasidone in a randomized, double-blind, placebo controlled, 3-dose/3- session, crossover design study