Aug 24, 2022 20:21
1 yr ago
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English term
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exosite interaction motif
English to Serbian
Medical
Medical: Pharmaceuticals
chimeric proteins
In some embodiments, a cleavable linker comprises an a1 region from FVIII, an a2 region from FVIII, an a3 region from FVIII, a thrombin cleavable site which comprises X-V-P-R (SEQ ID NO: 105) and a PARI exosite interaction motif, wherein X is an aliphatic amino acid, or any combinations thereof
References
| it should read PAR1, not PARI |
liz askew
|
Reference comments
52 mins
Reference:
it should read PAR1, not PARI
Protease activated receptor
Protease-activated receptor-1 (PAR1) is a GPCR for the serine protease thrombin. PAR1 mediates thrombin signaling in human platelets, endothelial cells, and fibroblasts and appears to play an important role in hemostasis and thrombosis, embryonic development and other processes (see refs.
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Note added at 55 mins (2022-08-24 21:17:07 GMT)
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=
proteazom aktivirani receptori
https://scindeks-clanci.ceon.rs/data/pdf/0301-0619/2013/0301...
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Note added at 1 hr (2022-08-24 21:28:01 GMT)
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exosite:
Funkcionalna analiza genskih varijanti FIIc.1787G>A (protrombin ...
https://nardus.mpn.gov.rs › bitstream › Disertacija
PDF
Prothrombin is a zymogen of thrombin (coagulation factor II), ... domena sa anjon-vezujućim mestom II (engl. exosite II) u trombinu, smanjuje se.
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Note added at 11 hrs (2022-08-25 07:29:16 GMT)
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Kringl 2 domen čini fragment 2 protrombina [23]. Interakcijom Kringl 2
domena sa anjon-vezujućim mestom II (engl. exosite II) u trombinu, smanjuje se
prokoagulantna aktivnost trombina, sprečava se inaktivacija trombina antitrombinom i
dolazi do poremećaja u Ca2+ zavisnoj aktivaciji proteina C [25-27].
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Note added at 11 hrs (2022-08-25 07:35:26 GMT)
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A Dynamic View of Domain-Motif Interactions - PLOS
https://journals.plos.org › ploscompbiol › article › journal...
by E Akiva · 2012 · Cited by 65 — Many protein-protein interactions are mediated by domain-motif interaction, where a domain in one protein binds a short linear motif in its ...
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Note added at 11 hrs (2022-08-25 07:36:51 GMT)
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http://scindeks.ceon.rs/article.aspx?artid=0004-19631105464R
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Note added at 11 hrs (2022-08-25 07:42:32 GMT)
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https://naucnenovosti.me/kako-se-proteini-vezuju-za-specific...
Prosječan ljudski protein se sastoji od približno 400 građevnih blokova zvanih aminokiseline, koji su nanizani zajedno i presavijeni u složenu 3D strukturu. Unutar ovog dugačkog niza građevnih blokova, neki proteini sadrže delove od 4-6 aminokiselina koje se nazivaju kratkim linearnim motivima (short linear motifs -SLiMs), koji posreduju u protein-protein interakcijama
Protease-activated receptor-1 (PAR1) is a GPCR for the serine protease thrombin. PAR1 mediates thrombin signaling in human platelets, endothelial cells, and fibroblasts and appears to play an important role in hemostasis and thrombosis, embryonic development and other processes (see refs.
--------------------------------------------------
Note added at 55 mins (2022-08-24 21:17:07 GMT)
--------------------------------------------------
=
proteazom aktivirani receptori
https://scindeks-clanci.ceon.rs/data/pdf/0301-0619/2013/0301...
--------------------------------------------------
Note added at 1 hr (2022-08-24 21:28:01 GMT)
--------------------------------------------------
exosite:
Funkcionalna analiza genskih varijanti FIIc.1787G>A (protrombin ...
https://nardus.mpn.gov.rs › bitstream › Disertacija
Prothrombin is a zymogen of thrombin (coagulation factor II), ... domena sa anjon-vezujućim mestom II (engl. exosite II) u trombinu, smanjuje se.
--------------------------------------------------
Note added at 11 hrs (2022-08-25 07:29:16 GMT)
--------------------------------------------------
Kringl 2 domen čini fragment 2 protrombina [23]. Interakcijom Kringl 2
domena sa anjon-vezujućim mestom II (engl. exosite II) u trombinu, smanjuje se
prokoagulantna aktivnost trombina, sprečava se inaktivacija trombina antitrombinom i
dolazi do poremećaja u Ca2+ zavisnoj aktivaciji proteina C [25-27].
--------------------------------------------------
Note added at 11 hrs (2022-08-25 07:35:26 GMT)
--------------------------------------------------
A Dynamic View of Domain-Motif Interactions - PLOS
https://journals.plos.org › ploscompbiol › article › journal...
by E Akiva · 2012 · Cited by 65 — Many protein-protein interactions are mediated by domain-motif interaction, where a domain in one protein binds a short linear motif in its ...
--------------------------------------------------
Note added at 11 hrs (2022-08-25 07:36:51 GMT)
--------------------------------------------------
http://scindeks.ceon.rs/article.aspx?artid=0004-19631105464R
--------------------------------------------------
Note added at 11 hrs (2022-08-25 07:42:32 GMT)
--------------------------------------------------
https://naucnenovosti.me/kako-se-proteini-vezuju-za-specific...
Prosječan ljudski protein se sastoji od približno 400 građevnih blokova zvanih aminokiseline, koji su nanizani zajedno i presavijeni u složenu 3D strukturu. Unutar ovog dugačkog niza građevnih blokova, neki proteini sadrže delove od 4-6 aminokiselina koje se nazivaju kratkim linearnim motivima (short linear motifs -SLiMs), koji posreduju u protein-protein interakcijama
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