English to Russian Science Medical (general)

Food and Chemical Toxicology 68 (2014) 204-217
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Food and Chemical Toxicology
journal homepage: www.elsevier.com/locate/foodchemtox

This approach identified genes which had a *high fold-change in expression* compared to sham: two (Hmoxl and Srxnl) in the RNE, eight (including Cyplal and Prr5l) in the bronchi, and five (including Fam46b and Nrcam) in the parenchyma; the expression of most of these genes were also seen in the 3R4F compared with the sham group in the respective tissues (Supplemental Table 10).
For a more detailed description, see Supplemental Results S2.3.
GSEA was used to detect biological activity unique to pMRTP exposure.
GSEA provides enhanced sensitivity and is more comprehensive than relaxing the statistical threshold because it focuses on groups of genes (so-called gene sets) that share common biological functions (Subramanian et al., 2005).