Feb 5, 2015 18:31
9 yrs ago
English term

Delayed Switch Group

English to French Medical Medical: Pharmaceuticals essais cliniques
I got this long explanation but I still don't know what is the accepted translation for this in the field:

Merci d'avance!

Common phase III clinical study designs consider issues of timing and switching. The “testing of timing” study design depicts a situation in which the optimal time to initiate therapy is unknown. The study team has selected 2 points in the clinical course of the disease to investigate. Patient entry and randomization is set at the earlier of these points and patients are randomized to the standard therapy or a “delay” arm. The subsequent trigger point (most often a clinical or laboratory event) on the delay arm would determine the initiation of the standard therapy for that group of patients. A comparison of results for these 2 groups would clarify the advantages of a delay in therapy initiation, if any.

Similarly, the “testing of switching” study design gives a strategy for evaluation of a switch from the standard therapy to a new experimental therapy. All patients would be treated on standard therapy up to a specific point, often a chronological time or a clinical or laboratory event, at which point the patients would enter the study and be randomly assigned to continue the current standard therapy or switch to the new experimental therapy. The value of the switch could then be evaluated by a direct comparison of the 2 randomized groups.

Proposed translations

+1
1 hr
Selected

Groupe assigné au transfert de thérapie (décalé dans le temps)

C’est un peu long mais « retardé » je trouve que ça fait un peu accidentel, alors que là c’est programmé…


http://www.bd.com/fr/diabetes/page.aspx?cat=6979&id=63279

"De nombreuses études portaient sur des transferts (switch), chez des patients DT2, de divers traitements (sitagliptine, exénatide) vers le liraglutide."

http://pvsq.org/2012/07/therapie-antiretrovirale-essais-clin...

"L’étude SPIRIT est la première qui a évalué le transfert (switch) d’une thérapie à base d’inhibiteur de la protéase vers cette combinaison simple et unique "

http://www.researchgate.net/publication/257736171

"we report data from the Algerian cohort switching from human insulin (HI) to insulin analogs./ <>Le transfert des insulines humaines vers les analogues de l’insuline "
Peer comment(s):

agree GILLES MEUNIER
38 mins
Merci Gilou!
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4 KudoZ points awarded for this answer. Comment: "Merci beaucoup!"
+1
12 mins

groupe soumis à un changement/remlacement /switch thérapeutique retardé

VIH: Le switch thérapeutique qui améliore les lipides - Le ...
seroposition.canalblog.com › MEDICAMENTS
18 oct. 2013 - VIH: Le switch thérapeutique qui améliore les lipides ... dans le bras qui a fait le changement après 6 mois la réduction des triglycérides était ... le cholestérol HDL dans le groupe soumis au changemant de thérapie ( passé de ...

Associations thérapeutiques dans la prise en charge des ...
www.em-consulte.com/en/article/179183
Rationnel des combinaisons thérapeutiques et choix des médicaments pour les ..... le remplacement (« switch ») de la molécule par une autre, ou l'addition d'un .... la combinaison thérapeutique retarde l'émergence de variants génétiques ...
Peer comment(s):

agree PLR TRADUZIO (X) : http://www.ema.europa.eu/docs/fr_FR/document_library/EPAR_-_...
15 hrs
Thank you.
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