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English to Russian translations [PRO]
Tech/Engineering - Genetics | | English term or phrase: germlining | в таком контексте
Altering antibodies in this way is called “germlining” and is routinely used in the art to generate antibody derivatives with similar binding properties but reduced immunogenicity in a human patient. |
| | | гуманизирование | Explanation:
Гуманизирование антител - замена отдельных аминокислот таким образом, чтобы антитела были больше похожи на человеческие и вызывали более слабый иммунный ответ в организме человека.
Germlining was performed by substituting the few deviating residues within the framework regions by those occurring in the best matching human germline segments. The identity score of the Framework Regions (typically around 90% for the wild type variable regions) could be improved without loss of affinity and potency to 95 – 99%, what is comparable with antibodies generated by fully human technologies.
http://www.wddsummit.com/speakers.asp
arGEN-X then uses these to produce
variable antibody regions with 96-99% human sequence homology via minimal germlining (humanization).
https://docs.google.com/viewer?url=http://www.erasmusmcfund....
Кроме обозначенных тем в лаборатории проводится работа по гуманизированию противовирусных моноклональных антител и запускается работа ...
http://scipeople.ru/vacancy/72/
Для гуманизирования антител теперь можно применять такие способы, как ПЦР (см., например, европейский патент 0368684; европейский патент 0438310; ...
ru-patent.info/21/90-94/2193779.html
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Note added at 5 час (2010-10-25 14:40:55 GMT)
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Вот цитата из Википедии, по ней видно, что, по крайней мере, в контексте Вашего вопроса гуманизирование и "germlining" можно использовать взаимозаменяемо, как во 2 из приведенных мною цитат:
Humanized antibodies are antibodies from non-human species whose protein sequences have been modified to increase their similarity to antibody variants ...
http://en.wikipedia.org/wiki/Humanized_antibody
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| Selected response from:
 Igor_2006
Russian Federation
Local time: 05:36
| Grading comment | 4 KudoZ points were awarded for this answer |
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| Discussion entries: 0 |
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Automatic update in 00:
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19 mins confidence:   гуманизирование
Explanation:
Гуманизирование антител - замена отдельных аминокислот таким образом, чтобы антитела были больше похожи на человеческие и вызывали более слабый иммунный ответ в организме человека.
Germlining was performed by substituting the few deviating residues within the framework regions by those occurring in the best matching human germline segments. The identity score of the Framework Regions (typically around 90% for the wild type variable regions) could be improved without loss of affinity and potency to 95 – 99%, what is comparable with antibodies generated by fully human technologies.
http://www.wddsummit.com/speakers.asp
arGEN-X then uses these to produce
variable antibody regions with 96-99% human sequence homology via minimal germlining (humanization).
https://docs.google.com/viewer?url=http://www.erasmusmcfund....
Кроме обозначенных тем в лаборатории проводится работа по гуманизированию противовирусных моноклональных антител и запускается работа ...
http://scipeople.ru/vacancy/72/
Для гуманизирования антител теперь можно применять такие способы, как ПЦР (см., например, европейский патент 0368684; европейский патент 0438310; ...
ru-patent.info/21/90-94/2193779.html
--------------------------------------------------
Note added at 5 час (2010-10-25 14:40:55 GMT)
--------------------------------------------------
Вот цитата из Википедии, по ней видно, что, по крайней мере, в контексте Вашего вопроса гуманизирование и "germlining" можно использовать взаимозаменяемо, как во 2 из приведенных мною цитат:
Humanized antibodies are antibodies from non-human species whose protein sequences have been modified to increase their similarity to antibody variants ...
http://en.wikipedia.org/wiki/Humanized_antibody
| Igor_2006
Russian Federation
Local time: 05:36
Specializes in field
Native speaker of:  Russian
PRO pts in category: 81
|
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| Changes made by editors |
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| Nov 3, 2010 - Changes made by Igor_2006: | | Created KOG entry | KudoZ term => KOG term |
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