expérimentation animale expliquée dans plusieurs articles sur le web (chercher à "canine lobe"). En voici un:
Measurement of pulmonary blood flow by fractal analysis of flow heterogeneity in isolated canine lungs. Barman, S. A., L. L. McCloud, J. D. Catravas, and I. C. Ehrhart. Department of Pharmacology and Toxicology, Department of Physiology and Endocrinology, Vascular Biology Center, Medical College of Georgia, Augusta, Georgia 30912
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APStracts 3:0312A, 1996.
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Regional heterogeneity of lung blood flow can be measured by analyzing the relative dispersion (RD) of mass (weight)-flow data. Numerous studies have shown that pulmonary blood flow is fractal in nature, a phenomenon that can be characterized by the fractal dimension (D) and the RD for the smallest realizable volume element (piece size) termed RDref. Although information exists for the applicability of fractal analysis to pulmonary blood flow in whole animal models, little is known in isolated organs. Therefore, the present study was done to determine the effect of blood flow rate on the distribution of pulmonary blood flow in the isolated blood perfused canine lung lobe using fractal analysis. Four different radiolabeled microspheres (141Ce, 95Nb, 85Sr, and 51Cr), each 15 microns in diameter, were injected into the pulmonary lobar artery of isolated canine lung lobes (n=5) perfused at four different flow rates (Flow 1 = 0.42 +0.02 L/min; Flow 2 = 1.12 + 0.07 L/min; Flow 3 = 2.25 + 0.17 L/min; Flow 4 = 2.59 + 0.17 L/min) and the pulmonary blood flow distribution was measured.