Glossary entry (derived from question below)
English term or phrase:
antigen sink
Portuguese translation:
degradação de antígenos
English term
United States
Translator/Chemist/Engineer (BSc/MSc)
Native in: Portuguese (Variant: Brazilian) 
Works in: English to Portuguese, Portuguese to English, Italian to Portuguese
antigen sink
As mentioned above, although CD47 is overexpressed on cancer cells, the expression of CD47 in many normal tissues leads to the non-specific binding of antibodies targeting CD47 only to normal circulating cells, which causes antigen sink.
| 3 +1 | degradação de antígenos |
Mario Freitas
|
| 5 +1 | dissipação por antigénios (PT) ou antígenos (BR) |
pedrolmoura
|
| 4 | sequestro de antígenos |
Manuel Delgado
|
Apr 24, 2020 17:48: Mario Freitas Created KOG entry
Jan 22, 2022 22:57: Mario Freitas changed "Field" from "Science" to "Medical"
Proposed translations
Brazil
32 years engineering/law/contracts
Native in: English (Variant: US) , Portuguese (Variant: Brazilian) 
Works in: English to Portuguese, Portuguese to English
Fast and accurate translations.
Native in: English , Portuguese
Works in: English to Portuguese, Portuguese to English, Spanish to English, and 3 more.
dissipação por antigénios (PT) ou antígenos (BR)
"Typically, clearance of mAb that binds to membrane antigen is faster at low doses as the unbound targets will “sop up” antibody, serving as a sink (this phenomenon is referred to as the “antigen sink”)."
"While CD47 is overexpressed on cancer cells, its expression in many normal tissues may create an 'antigen sink' that could minimize the therapeutic efficacy of CD47 blocking agents."
Ora depreende-se que os antigénios em si não são afectados; são sim os anticorpos, cuja presença e acção é dissipada (sink = dissipador, e.g. heat sink = dissipador de calor) devido à ligação a células que não são os alvos da terapia por conterem os antigénios em questão nas suas membranas.
| agree |
Mario Freitas
: Este é o clima, cara. Assim você vai bem. Abraços.
23 mins
|
|
Obrigado, Mário!
|
Medical & Pharma translation since 1973
Native in: Portuguese (Variants: Brazilian, European/Portugal)
Works in: English to Portuguese, French to Portuguese
sequestro de antígenos
| neutral |
pedrolmoura
: Embora seja uma possível tradução directa, em português o sequestro de antigénios é um fenómeno distinto e ligado à autoimunidade (http://www.unirio.br/ppgbmc/dissertacao-rejane-silva)
5 mins
|
Something went wrong...