Nov 21, 2014 11:32
9 yrs ago
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English term

head to head vs active comparators

English to Polish Medical Medical (general) badnaie kliniczne
It is also important to note that PRODUCT X is supported by an extensive clinical trial program with over 200 patients that included 8 phase 2 trials of which 2 are head to head vs active comparators.

Proposed translations

4 hrs
Selected

bezpośrednie porównanie z innymi aktywnymi lekami

ew. zamiast "aktywnymi lekami" "lekami stosowanymi w ..."
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Reference comments

1 hr
Reference:

head to head vs active comparator-s

Por:
Comparator może, lecz nie musi występować tutaj w znaczeniu:
preparat/ produkt lek porównawczy (odwoławczy)
przy czym head-to-head (head to head) oznaczałoby- bezpośredni (m. inn)
natomiast active- czynny.

Comparator ma jednak także inne znaczenia, które należy przeanalizować i uwzględnić.

Por LINKI: (zostaną dodane)



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Note added at   1 godz. (2014-11-21 12:58:19 GMT)
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Comparator- Definition: (definicje powszechne, bez zależności bezp. z kontekstem)

Definition 1:

Instrument for comparing something with a similar thing or with a standard measure, in particular to measure small displacements in mechanical devices. In astronomy, the blink comparator is used to examine photographic plates for signs of moving bodies. Machinists use comparators or visual gauges to centre or align work in MACHINE TOOLs.

http://www.merriam-webster.com/dictionary/comparator


Definition 2:
NOUN
A device for comparing something measurable with a reference or standard.
http://www.oxforddictionaries.com/definition/english/compara...


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Note added at   1 godz. (2014-11-21 13:14:08 GMT)
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Comparator-s in medicine/ clinical trials:

Examples in sentences:
Example 1: ACTIVE COMPARATOR ARM

A group of participants that receives an intervention that is considered to be effective. One of several Arm Types.

Example 2:
Comparator Clinical Trials: What are they and what you need to consider


The point of a clinical trial is the see if a medical treatment (e.g., drug, device, biologic) is 1) safe, and 2) effective for treating the target medical condition. The way this has often been done is to randomly put subjects into 2 groups and give one group the treatment (I'll use the example of a drug for simplicity) and the other group a placebo. The placebo is commonly thought of in the public eye as "a sugar pill". This isn't really accurate, but the idea is close to reality, namely that the placebo is an inert treatment that has no active medical ingredient in it, but looks and feels indistinguishable from the drug. This way, the subjects (and often the doctors) do not know which group is getting the drug and which group is getting the placebo. This helps prevent any bias in the way people respond.

As an aside, note that I use the term "subjects" for clinical trial participants, not "patients". Clinical trial participants are not patients because the treatment being tested is experimental and should not be considered therapy. In fact, the treatment may even be harmful. The whole point of the trial is to determine this issue. Therefore, clinical trial participants, who have graciously and generously agreed voluntarily to put their health at risk for the sake of the trial, are "subjects", not "patients".

Ok, back to the topic at hand.
WAŻNE:

A recent trend in the clinical trial field is to do a comparator trial, rather than a placebo-controlled trial. This means that the experimental drug is not being compared to a placebo, but rather to a drug that is already being used to treat patients. There are several reasons for this trend.
http://timgrammerblog.blogspot.com/2009/04/comparator-clinic...

Example 3: PDF- Choice of Control in Clinical trials II
An active control is an agent used as a comparator in a clinical trial .
Example 4: (DEFINICJA + inne definicje związane z clinical trials)
Active comparator: An arm or group in which active drugs are given. ...
http://www.cancer.gov/clinicaltrials/conducting/ncictrp/reso...
Example 5: Clinical trials of Pharmaceutical Agents- WAŻNE
Clinical trial of pharmaceutical agents is the necessary step required for ... probability of receiving investigational or control study drug (comparator or placebo).
http://www.medtran.ru/eng/trials/clinicaltrials.htm
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