English to Polish Medical Medical (general)

For all patients, if the true HR is 0.7 under the alternative hypothesis, a total of 425 OS events will be required to have 93% power to detect a HR of 0.7 using a onesided log rank test at a significance level of 0.015 and a 2-look group-sequential design with LanDeMets (O’Brien-Fleming) spending function to determine the efficacy boundary.