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Specializes in:
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Medical: Cardiology
Medical: Dentistry
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English to Portuguese - Rates: 0.20 - 0.25 USD per word / 120 - 125 USD per hour / 2.00 - 2.00 USD per audio/video minute Portuguese to English - Rates: 0.20 - 0.25 USD per word / 120 - 125 USD per hour / 2.00 - 2.00 USD per audio/video minute Portuguese - Rates: 0.20 - 0.25 USD per word / 120 - 125 USD per hour / 2.00 - 2.00 USD per audio/video minute English - Rates: 0.20 - 0.25 USD per word / 120 - 125 USD per hour / 2.00 - 2.00 USD per audio/video minute
Portuguese to English: ABSTRACT General field: Science Detailed field: Science (general)
Source text - Portuguese RESUMO
A programação metabólica é um fenômeno provindo de experiências nutricionais no início da vida e que podem levar a desordens metabólicas na vida adulta. Um dos modelos de programação é a manipulação do tamanho da ninhada,
formando ninhadas de tamanho reduzido ou expandido, resultando em alterações no aporte nutritivo para mais (obesidade) ou para menos (subnutrição), respectivamente. Esses procedimentos resultam em alterações de peso corporal e metabólicas desde a infância até a vida adulta, evidenciando que o estado fisiológico do organismo no período pós-natal é extremamente relevante para o desenvolvimento e homeostase do organismo. Além disso, especula-se que, assim como a supernutrição, a má- nutrição possa causar prejuízos no desenvolvimento sexual e reprodutivo de fêmeas, afetando, inclusive, o desenvolvimento da prole por gerações. Desta forma, o objetivo deste trabalho foi avaliar a prole de machos de mães provenientes de ninhadas de tamanho normal e expandida. Para tanto, foi avaliado o peso corporal, ingestão alimentar e desenvolvimento sexual desta prole de machos do nascimento até o nonagésimo dia após nascimento, quando foram submetidos à eutanásia para avaliação de parâmetros plasmáticos (glicose, ácidos graxos, triglicérides, colesterol total e testosterona), e determinação do peso dos tecidos adiposos brancos viscerais, adrenal e testículos. Foi observado que o peso corporal da prole masculina de mães de ninhada expandida diminuiu, apesar da ingestão alimentar ter sido maior, comparados com a prole normal. A prole masculina de mães de ninhada expandida apresentaram maior distância nasoanal e redução do Índice de Lee no DPN 90. A prole masculina de mães de ninhada expandida também apresentou menor resposta glicêmica e concentração plasmática de triglicérides comparado a prole masculina de mães de ninhada normal. Portanto, pode-se concluir que a subnutrição materna promove efeitos metabólicos em sua prole, pelo menos em parte benéficos, como diminuição do ganho de peso corporal e trigliceridemia, aumento da tolerância à glicose, e maior crescimento longitudinal.
Translation - English Metabolic programming is a phenomenon caused by nutritional experiences in early life, which can lead to metabolic disorders in adult life. One of the programming models is the manipulation of the litter size, which results in small or large litters accounting to positive (obesity) or negative (malnutrition) nutritional status, respectively. These procedures result in body weight and metabolic changes from childhood to adulthood, showing that the physiological conditions in the postnatal period is extremely relevant for the body's development and homeostasis. Furthermore, it is speculated that, as overnutrition, malnutrition can impair the sexual and reproductive development of females, even affecting the development of offspring for generations. Thus, the objective of this work was to evaluate the male offspring from moms from normal (NL) and large litters (LL). For this purpose, body weight, food intake and sexual development of male offspring from birth, postnatal day (PND) 0, to PND 90 were evaluated, when they were euthanized to obtain blood for determination of plasma parameters (glucose, fatty acids, triglycerides, total cholesterol and testosterone), and weights of visceral white adiposes tissues, adrenal and testis. The body weight of male offspring of mothers from expanded litters was lower, although food intake was higher, compared to normal litter. Male offspring of mothers raised in large litter rats showed increased nasoanal distance and a reduced Lee Index on the PND 90. Male offspring from expanded litter mothers also had a lower glycemic response and plasma triglyceride concentration compared to male offspring from normal litter mothers. Therefore, it can be concluded that maternal malnutrition promotes metabolic effects in their male offspring, which seem to at least in part beneficial, such as lower body weight gain and triglyceridemia, increased glucose tolerance, and higher longitudinal growth.
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Years of experience: 2. Registered at ProZ.com: Apr 2020.
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