Glossary entry (derived from question below)
English term or phrase:
AST
English answer:
aspartate aminotransferase
Added to glossary by
Veronica Prpic Uhing
Nov 27, 2004 17:38
20 yrs ago
2 viewers *
English term
AST
English
Other
Chemistry; Chem Sci/Eng
aspartate aminotransferase (AST)
aspartate transaminase (AST)
what is the difference? are they the same thing? is transaminase the new name - i.e. aminotransferase formerly known as transaminase (see eurodicautom)
how fundamental is it to use the new name (if this is the case).
thanks
aspartate transaminase (AST)
what is the difference? are they the same thing? is transaminase the new name - i.e. aminotransferase formerly known as transaminase (see eurodicautom)
how fundamental is it to use the new name (if this is the case).
thanks
Responses
| 5 | Info |
Veronica Prpic Uhing
|
| 4 +2 | aspartate aminotransferase called also aspartate transaminase |
Selcuk Akyuz
|
| 5 +1 | aspartate aminotransferase |
Elena Sgarbo (X)
|
Responses
2 hrs
Veronica Prpic Uhing
United States
United States
Specializes in field
United States
Looking for something to translate!
Native in: Croatian
Works in: Croatian to English, English to Croatian, English to Bosnian, and 12 more.
Related KudoZ points
:
35
Selected
Info
Info
According to IUBMB (International Union of Biochemistry and Molecular Biology)enzyme nomenclature
AST enzyme is classified as EC 2.6.1.1
Common name is: aspartate transaminase
Systematic name: L-aspartate:2-oxoglutarate aminotransferase
Other names include also - aspartate aminotransferase
Since aminotransferase is an enzyme that catalyzes the transfer of an amino group from a donor molecule to a recipient molecule
aspartate aminotransferase is more appropriate unless you need systematic name
http://www.chem.qmul.ac.uk/iubmb/enzyme/EC2/6/1/1.html
http://www.medterms.com/script/main/art.asp?articlekey=6591
International Union of Biochemistry and Molecular Biology
--------------------------------------------------
Note added at 2 hrs 41 mins (2004-11-27 20:20:17 GMT)
--------------------------------------------------
http://www.iubmb.unibe.ch/
According to IUBMB (International Union of Biochemistry and Molecular Biology)enzyme nomenclature
AST enzyme is classified as EC 2.6.1.1
Common name is: aspartate transaminase
Systematic name: L-aspartate:2-oxoglutarate aminotransferase
Other names include also - aspartate aminotransferase
Since aminotransferase is an enzyme that catalyzes the transfer of an amino group from a donor molecule to a recipient molecule
aspartate aminotransferase is more appropriate unless you need systematic name
http://www.chem.qmul.ac.uk/iubmb/enzyme/EC2/6/1/1.html
http://www.medterms.com/script/main/art.asp?articlekey=6591
International Union of Biochemistry and Molecular Biology
--------------------------------------------------
Note added at 2 hrs 41 mins (2004-11-27 20:20:17 GMT)
--------------------------------------------------
http://www.iubmb.unibe.ch/
4 KudoZ points awarded for this answer.
Comment: "many thanks to all, especially Elena. I'll go for the extra info which had not occurred to me. "
+2
3 mins
Selcuk Akyuz
Türkiye
Türkiye
Türkiye
English to Turkish translator
Native in: Turkish
Works in: English to Turkish, Turkish to English, Turkish
Related KudoZ points
:
4
aspartate aminotransferase called also aspartate transaminase
according to Merriam Webster's Medical Desk Dictionary
aspartate aminotransferase
n : an enzyme promoting transfer of an amino group from glutamic acid to oxaloacetic acid and which when present in abnormally high levels in the blood is a diagnostic indication of myocardial infarction or liver disease —called also aspartate transaminase, glutamic-oxaloacetic transaminase
--------------------------------------------------
Note added at 10 mins (2004-11-27 17:49:38 GMT)
--------------------------------------------------
and according to Dorland\'s Medical Dictionary
aspartate aminotransferase (as·par·tate ami·no·trans·fer·ase) aspartate transaminase.
aspartate transaminase (as·par·tate trans·am·i·nase) an enzyme of the transferase class that catalyzes the reversible transfer of an amino group from aspartate to a-ketoglutarate to form glutamate and oxaloacetate, with pyridoxal phosphate required as a cofactor. The enzyme is present in most eukaryotic cells, occurring as distinct isozymes in mitochondria and cytosol. Both isozymes participate in the malate-aspartate shuttle, and in the liver the reaction transfers excess metabolic nitrogen into aspartate for disposal via the urea cycle. The serum level of aspartate transaminase (SGOT) and that of other transaminases are frequently elevated in a variety of disorders causing tissue damage (e.g., myocardial infarction).
Abbreviated AST and ASAT.
Called also aspartate aminotransferase and glutamic-oxaloacetic transaminase (GOT).
aspartate aminotransferase
n : an enzyme promoting transfer of an amino group from glutamic acid to oxaloacetic acid and which when present in abnormally high levels in the blood is a diagnostic indication of myocardial infarction or liver disease —called also aspartate transaminase, glutamic-oxaloacetic transaminase
--------------------------------------------------
Note added at 10 mins (2004-11-27 17:49:38 GMT)
--------------------------------------------------
and according to Dorland\'s Medical Dictionary
aspartate aminotransferase (as·par·tate ami·no·trans·fer·ase) aspartate transaminase.
aspartate transaminase (as·par·tate trans·am·i·nase) an enzyme of the transferase class that catalyzes the reversible transfer of an amino group from aspartate to a-ketoglutarate to form glutamate and oxaloacetate, with pyridoxal phosphate required as a cofactor. The enzyme is present in most eukaryotic cells, occurring as distinct isozymes in mitochondria and cytosol. Both isozymes participate in the malate-aspartate shuttle, and in the liver the reaction transfers excess metabolic nitrogen into aspartate for disposal via the urea cycle. The serum level of aspartate transaminase (SGOT) and that of other transaminases are frequently elevated in a variety of disorders causing tissue damage (e.g., myocardial infarction).
Abbreviated AST and ASAT.
Called also aspartate aminotransferase and glutamic-oxaloacetic transaminase (GOT).
+1
1 hr
aspartate aminotransferase
Hi Mbatrad,
I'd update the enzyme name. As you know, it was formerly called "GOT"= glutamate-oxaloacetate transaminase, was then called "AST= aspartate transaminase" but lately it's referred to as "AST= aspartate aminotransferase".
The word "transaminase(s)" to refer to the AST is still used when both AST and ASL are mentioned as a group (see example below).
Good luck,
Elena
a·mi·no·trans·fer·ase (-mn-trnsf-rs, -rz, m-n-)
n.
Any of various enzymes that catalyze the transfer of an amino group between an alpha-amino acid and usually a specific carbon on a keto acid. Also called aminopherase, transaminase.
http://dictionary.reference.com/search?q=aminotransferase&r=...
His LFT remained normal during January 2000, but his serum transaminases were found elevated on February 2000 ** (aspartate aminotransferase [AST] ** 206, alanine aminotransferase [ALT] 266). A liver biopsy then showed no evidence of TB or cytomegalovirus disease. The patient continued to have stable elevation of his ** serum AST ** and ALT until late March 2000 when a repeat liver biopsy showed caseating granuloma. The patient was started on anti-TB medications, with which he was compliant. By mid-May 2000 he was doing well, with significant reduction in his ** transaminase levels (AST 72, ALT 79) **
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&d...
--------------------------------------------------
Note added at 1 hr 56 mins (2004-11-27 19:35:36 GMT)
--------------------------------------------------
:::::::: Sorry about extra-floating the page -- it\'s probably my browser, Mozilla Firefox....
I'd update the enzyme name. As you know, it was formerly called "GOT"= glutamate-oxaloacetate transaminase, was then called "AST= aspartate transaminase" but lately it's referred to as "AST= aspartate aminotransferase".
The word "transaminase(s)" to refer to the AST is still used when both AST and ASL are mentioned as a group (see example below).
Good luck,
Elena
a·mi·no·trans·fer·ase (-mn-trnsf-rs, -rz, m-n-)
n.
Any of various enzymes that catalyze the transfer of an amino group between an alpha-amino acid and usually a specific carbon on a keto acid. Also called aminopherase, transaminase.
http://dictionary.reference.com/search?q=aminotransferase&r=...
His LFT remained normal during January 2000, but his serum transaminases were found elevated on February 2000 ** (aspartate aminotransferase [AST] ** 206, alanine aminotransferase [ALT] 266). A liver biopsy then showed no evidence of TB or cytomegalovirus disease. The patient continued to have stable elevation of his ** serum AST ** and ALT until late March 2000 when a repeat liver biopsy showed caseating granuloma. The patient was started on anti-TB medications, with which he was compliant. By mid-May 2000 he was doing well, with significant reduction in his ** transaminase levels (AST 72, ALT 79) **
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&d...
--------------------------------------------------
Note added at 1 hr 56 mins (2004-11-27 19:35:36 GMT)
--------------------------------------------------
:::::::: Sorry about extra-floating the page -- it\'s probably my browser, Mozilla Firefox....
Discussion
ALT reaction is -- L-alanine + 2-oxoglutarate = pyruvate + L-glutamate
AST reaction is --- L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate
it should be Asparate Aminotransferase (AST)
Should I assume it's a mistake? I guess...
any thoughts on: Asparate Aminotransferase (ALT)(in English)
copyrighter was tired?
am I missing out on something?