Jun 5, 2008 10:51
16 yrs ago
1 viewer *
Spanish term
15% superioridad de la combinación/superior a
Spanish to English
Medical
Medical: Pharmaceuticals
Drug protocol
I would be grateful for help with this term, and general help with this whole sentence (basically somebody to say it is OK).
Dado que con XXXX se espera un éxito a las 12 semanas de un 55% y estimando una pérdida de un 25% de pacientes por su enfermedad de base, para demostrar un 15% de superioridad de la combinación sobre la monoterapia, se requeriría un no. de 324 pacientes. Si la combinación resultará ser un 10% superior a la monoterapia el no. sería de 752 pacientes.
Here is my version:
Given that a success rate of 55%9 is expected at 12 weeks using Voriconazole, and estimating a loss of 25% of patients due to underlying disease, in order to show a 15% superiority of the combination therapy over the monotherapy, a total of 324 patients would be required. If the combination therapy is 10% higher than the monotherapy the number of patients would be 752.
Thank you!
Liz Askew
Dado que con XXXX se espera un éxito a las 12 semanas de un 55% y estimando una pérdida de un 25% de pacientes por su enfermedad de base, para demostrar un 15% de superioridad de la combinación sobre la monoterapia, se requeriría un no. de 324 pacientes. Si la combinación resultará ser un 10% superior a la monoterapia el no. sería de 752 pacientes.
Here is my version:
Given that a success rate of 55%9 is expected at 12 weeks using Voriconazole, and estimating a loss of 25% of patients due to underlying disease, in order to show a 15% superiority of the combination therapy over the monotherapy, a total of 324 patients would be required. If the combination therapy is 10% higher than the monotherapy the number of patients would be 752.
Thank you!
Liz Askew
Proposed translations
(English)
5 | I agree (but) | FFeNiXx |
5 +1 | 15% improvement with the combination compared to... | David Brown |
4 | 15% advantage of combination therapy over monotherapy | Andres Larsen |
Proposed translations
6 mins
Selected
I agree (but)
I completely agree, the only thing I would change in your text is "a loss of 25% of patients" to "a 25% loss of patients". Otherwise, everything else seems perfect.
4 KudoZ points awarded for this answer.
Comment: "I used the literal translation folks and changed the bit to "a loss of 25% of...".
Thank you!"
+1
1 hr
15% improvement with the combination compared to...
I suppose the "superiority" is measured by observing/measuring an improvement in one or more parameters
1 day 9 hrs
15% advantage of combination therapy over monotherapy
Given that with Voriconazole a 55% success rate is expected at 12 weeks, with an estimated 25% loss of patients due to baseline illness, to show a 15% advantage of combination therapy over monotherapy, 324 patients would be required as proof of concept, whereas a 10% advantage would require 752 patients.
see also:
Critical Care | Full text | Combination therapy versus monotherapy ...- [ Traducir esta página ]Pneumonia was not microbiologically confirmed in 15 of these patients: 4 in the C .... to demonstrate any advantage of combination therapy over monotherapy, ...
ccforum.com/content/10/2/R52 - 71k - En caché - Páginas similares
Combination therapy versus monotherapy: a randomised pilot study ...- [ Traducir esta página ]If this study failed to demonstrate any advantage of combination therapy over monotherapy, the use of empirical combination therapy remains probably ...
www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1550875 - Páginas similares
International Journal of Antimicrobial Agents : Combination ...- [ Traducir esta página ]In patients treated with empiric antibiotic therapy, combination therapy showed no advantage over monotherapy with β-lactam agent. Combination therapy was ...
linkinghub.elsevier.com/retrieve/pii/S0924857998000600 - Páginas similares
Combination Therapy for Rheumatoid Arthritis- [ Traducir esta página ]The recent Methotrexate and Sulfasalazine Combination Therapy (MASCOT) study .... did not show any clinical benefit over monotherapy with either agent. ...
www.medscape.com/viewarticle/560135_2 - Páginas similares
Comparison of {beta}-Lactam and Macrolide Combination Therapy ...... the advantages of combination therapy over monotherapy for severe CAP (5, ... Severity Index [PSI] scoring system [15] and the Acute Physiological and ...
aac.asm.org/cgi/content/full/51/11/3977 - Páginas similares
Direct Antilymphoma Effects on Human Lymphoma Cells of Monotherapy ...The results observed in this study show the advantages of combination therapy over monotherapy. The ability of the combinations to induce greater effects in ...
clincancerres.aacrjournals.org/cgi/content/full/11/19/7075s - Páginas similares
Beta lactam antibiotic monotherapy versus beta lactam ...- [ Traducir esta página ]In studies comparing different beta-lactams, we observed an advantage to ... We identified no difference between monotherapy and combination therapy in ...
www.cochrane.org/reviews/en/ab003344.html - 25k - En caché - Páginas similares
The role of combination therapy for lower urinary tract symptoms ...foundmostly in the combination therapy group. These recent. data have proven to have distinct advantages of combination. therapy over that of monotherapy ...
www.springerlink.com/index/91R255758580133M.pdf - Páginas similares
Chicago Journals - Clinical Infectious Diseases- [ Traducir esta página ]The second advantage of combination therapy is in the context of initial empirical ... The superiority of combination antifungal therapy over monotherapy in ...
www.journals.uchicago.edu/cgi-bin/resolve?CID33226 - Páginas similares
Nature Clinical Practice Rheumatology | Combination therapy for ...- [ Traducir esta página ]Mottonen and colleagues—in an open, but randomized, study—compared sequential monotherapy with initial triple DMARD combination therapy over 2 years.41 ...
www.nature.com/ncprheum/journal/v3/n8/full/ncprheum0562.htm... - Páginas similares
Dado que con XXXX se espera un éxito a las 12 semanas de un 55% y estimando una pérdida de un 25% de pacientes por su enfermedad de base, para demostrar un 15% de superioridad de la combinación sobre la monoterapia, se requeriría un no. de 324 pacientes. Si la combinación resultará ser un 10% superior a la monoterapia el no. sería de 752 pacientes.
Given that a success rate of 55%9 is expected at 12 weeks using Voriconazole, and estimating a loss of 25% of patients due to underlying disease, in order to show a 15% superiority of the combination therapy over the monotherapy, a total of 324 patients would be required. If the combination therapy is 10% higher than the monotherapy the number of patients would be 752.
see also:
Critical Care | Full text | Combination therapy versus monotherapy ...- [ Traducir esta página ]Pneumonia was not microbiologically confirmed in 15 of these patients: 4 in the C .... to demonstrate any advantage of combination therapy over monotherapy, ...
ccforum.com/content/10/2/R52 - 71k - En caché - Páginas similares
Combination therapy versus monotherapy: a randomised pilot study ...- [ Traducir esta página ]If this study failed to demonstrate any advantage of combination therapy over monotherapy, the use of empirical combination therapy remains probably ...
www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1550875 - Páginas similares
International Journal of Antimicrobial Agents : Combination ...- [ Traducir esta página ]In patients treated with empiric antibiotic therapy, combination therapy showed no advantage over monotherapy with β-lactam agent. Combination therapy was ...
linkinghub.elsevier.com/retrieve/pii/S0924857998000600 - Páginas similares
Combination Therapy for Rheumatoid Arthritis- [ Traducir esta página ]The recent Methotrexate and Sulfasalazine Combination Therapy (MASCOT) study .... did not show any clinical benefit over monotherapy with either agent. ...
www.medscape.com/viewarticle/560135_2 - Páginas similares
Comparison of {beta}-Lactam and Macrolide Combination Therapy ...... the advantages of combination therapy over monotherapy for severe CAP (5, ... Severity Index [PSI] scoring system [15] and the Acute Physiological and ...
aac.asm.org/cgi/content/full/51/11/3977 - Páginas similares
Direct Antilymphoma Effects on Human Lymphoma Cells of Monotherapy ...The results observed in this study show the advantages of combination therapy over monotherapy. The ability of the combinations to induce greater effects in ...
clincancerres.aacrjournals.org/cgi/content/full/11/19/7075s - Páginas similares
Beta lactam antibiotic monotherapy versus beta lactam ...- [ Traducir esta página ]In studies comparing different beta-lactams, we observed an advantage to ... We identified no difference between monotherapy and combination therapy in ...
www.cochrane.org/reviews/en/ab003344.html - 25k - En caché - Páginas similares
The role of combination therapy for lower urinary tract symptoms ...foundmostly in the combination therapy group. These recent. data have proven to have distinct advantages of combination. therapy over that of monotherapy ...
www.springerlink.com/index/91R255758580133M.pdf - Páginas similares
Chicago Journals - Clinical Infectious Diseases- [ Traducir esta página ]The second advantage of combination therapy is in the context of initial empirical ... The superiority of combination antifungal therapy over monotherapy in ...
www.journals.uchicago.edu/cgi-bin/resolve?CID33226 - Páginas similares
Nature Clinical Practice Rheumatology | Combination therapy for ...- [ Traducir esta página ]Mottonen and colleagues—in an open, but randomized, study—compared sequential monotherapy with initial triple DMARD combination therapy over 2 years.41 ...
www.nature.com/ncprheum/journal/v3/n8/full/ncprheum0562.htm... - Páginas similares
Dado que con XXXX se espera un éxito a las 12 semanas de un 55% y estimando una pérdida de un 25% de pacientes por su enfermedad de base, para demostrar un 15% de superioridad de la combinación sobre la monoterapia, se requeriría un no. de 324 pacientes. Si la combinación resultará ser un 10% superior a la monoterapia el no. sería de 752 pacientes.
Given that a success rate of 55%9 is expected at 12 weeks using Voriconazole, and estimating a loss of 25% of patients due to underlying disease, in order to show a 15% superiority of the combination therapy over the monotherapy, a total of 324 patients would be required. If the combination therapy is 10% higher than the monotherapy the number of patients would be 752.
Discussion
A Comparison of Cardiovascular Biomarkers in Patients Treated for Three Months ... The hypothesis was that etoricoxib would be non-inferior or superior to ...
www.blackwell-synergy.com/doi/abs/10.1111/j.1753-5174.2007....