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Novel aza-anthracenedione

Portuguese translation: nova aza-antraquinona OU derivado aza-antraquinônico novo/inovador... etc.

GLOSSARY ENTRY (DERIVED FROM QUESTION BELOW)
English term or phrase:Novel aza-anthracenedione
Portuguese translation:nova aza-antraquinona OU derivado aza-antraquinônico novo/inovador... etc.
Entered by: Michelle de Abreu Aio

16:59 Aug 20, 2012
English to Portuguese translations [PRO]
Medical - Medical: Pharmaceuticals
English term or phrase: Novel aza-anthracenedione
Aparece em uma lista de mecanismos de ação de um regime de quimioterapia. O trecho é:

Novel aza-anthracenedione synthesised to reduce anthracycline-related cardiotoxicity and not compromise antitumour efficacy

Não consigo encontrar a tradução para "novel aza-anthracenedione". Alguma dica?


Obrigada desde já!
Michelle de Abreu Aio
Brazil
Local time: 08:32
nova aza-antraquinona OU derivado aza-antraquinônico novo/inovador... etc.
Explanation:
Uma "aza-anthracenedione" é um composto químico que contém o núcleo benzoisoquinolina-5,10-diona. Algumas são úteis como agentes citotóxicos (mitoxantrona, pixantrona etc.) Na literatura em português, o costuma ser traduzido como "aza-antraquinona". Alguns exemplos:

http://sec.sbq.org.br/cd29ra/resumos/T0215-1.pdf
http://sec.sbq.org.br/cdrom/34ra/resumos/T2386-1.pdf
http://www.scielo.br/pdf/qn/v26n3/15668.pdf
http://www.eventosufrpe.com.br/jepex2009/cd/resumos/R0151-1....

Eu usaria "derivado aza-antraquinônico/derivado da aza-antraquinona". Também prefiro "inovador" a "novo" como tradução de "novel" no contexto de descoberta de fármacos... mas aí é uma questão pessoal.

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Note added at 27 mins (2012-08-20 17:27:09 GMT)
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Nesta imagem, por exemplo, o grupo "aza-anthracenedione" é o núcleo central com três anéis:
http://commons.wikimedia.org/wiki/File:Pixantrone.svg
Selected response from:

Filippe Vasconcellos de Freitas Guimarães
Brazil
Local time: 08:32
Grading comment
Obrigada!
4 KudoZ points were awarded for this answer



Summary of answers provided
4 +4nova aza-antraquinona OU derivado aza-antraquinônico novo/inovador... etc.
Filippe Vasconcellos de Freitas Guimarães
Summary of reference entries provided
synonym of anthracenedione = anthraquinone
liz askew

  

Answers


24 mins   confidence: Answerer confidence 4/5Answerer confidence 4/5 peer agreement (net): +4
novel aza-anthracenedione
nova aza-antraquinona OU derivado aza-antraquinônico novo/inovador... etc.


Explanation:
Uma "aza-anthracenedione" é um composto químico que contém o núcleo benzoisoquinolina-5,10-diona. Algumas são úteis como agentes citotóxicos (mitoxantrona, pixantrona etc.) Na literatura em português, o costuma ser traduzido como "aza-antraquinona". Alguns exemplos:

http://sec.sbq.org.br/cd29ra/resumos/T0215-1.pdf
http://sec.sbq.org.br/cdrom/34ra/resumos/T2386-1.pdf
http://www.scielo.br/pdf/qn/v26n3/15668.pdf
http://www.eventosufrpe.com.br/jepex2009/cd/resumos/R0151-1....

Eu usaria "derivado aza-antraquinônico/derivado da aza-antraquinona". Também prefiro "inovador" a "novo" como tradução de "novel" no contexto de descoberta de fármacos... mas aí é uma questão pessoal.

--------------------------------------------------
Note added at 27 mins (2012-08-20 17:27:09 GMT)
--------------------------------------------------

Nesta imagem, por exemplo, o grupo "aza-anthracenedione" é o núcleo central com três anéis:
http://commons.wikimedia.org/wiki/File:Pixantrone.svg

Filippe Vasconcellos de Freitas Guimarães
Brazil
Local time: 08:32
Specializes in field
Native speaker of: Native in EnglishEnglish, Native in PortuguesePortuguese
PRO pts in category: 180
Grading comment
Obrigada!

Peer comments on this answer (and responses from the answerer)
agree  Maria Teresa Borges de Almeida: Em PT(pt): aza-antracenediona
5 mins
  -> Muito obrigado, Teresa! Acho que em PT(br) também ficaria bem :)
agree  Marlene Curtis
1 hr
  -> Obrigado, Marlene!
agree  Fernanda Bardy
6 hrs
  -> Obrigado, Fernanda!
agree  Goyta' F. Villela Jr.
13 hrs
  -> Muito obrigado, Goytá!
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Reference comments


20 mins
Reference: synonym of anthracenedione = anthraquinone

Reference information:
http://dicionario.sensagent.com/anthraquinone/en-en/


Merriam Webster

Anthraquinone , n. (Chem.) A hydrocarbon, C6H4.C2O2.C6H4, subliming in shining yellow needles. It is obtained by oxidation of anthracene.
Wikipedia
Anthraquinone

9,10-Anthraquinone
IUPAC name

Anthraquinone
Other names

9,10-anthracenedione, anthradione, 9,10-anthrachinon, anthracene-9,10-quinone, 9,10-dihydro-9,10-dioxoanthracene, Hoelite, Morkit, Corbit
Identifiers
CAS number 84-65-1 Yes
ChemSpider 6522 Yes
KEGG C16207 Yes
ChEMBL CHEMBL55659
Jmol-3D images Image 1
SMILES

O=C1c2ccccc2C(=O)c3ccccc13

Properties
Molecular formula C14H8O2
Molar mass 208.21 g mol−1
Appearance yellow solid
Density 1.308g/cm3
Melting point

286 °C
Boiling point

379.8 °C
Solubility in water Insoluble
Hazards
R-phrases R36/37/38
Flash point 185°C
Related compounds
Related compounds quinone,
anthracene
(verify) (what is: Yes/?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Anthraquinone, also called anthracenedione or dioxoanthracene is an aromatic organic compound with formula C14H8O2. Several isomers are possible, each of which can be viewed as a quinone derivative. The term anthraquinone, however, almost invariably refers to one specific isomer, 9,10-anthraquinone (IUPAC: 9,10-dioxoanthracene) wherein the keto groups are located on the central ring. It is a building block of many dyes and is used in bleaching pulp for papermaking. It is a yellow highly crystalline solid, poorly soluble in water but soluble in hot organic solvents. For instance, it is almost completely insoluble in ethanol near room temperature but 2.25 g will dissolve in 100 g of boiling ethanol.

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Note added at 22 mins (2012-08-20 17:22:18 GMT)
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The Role of Anthracyclines/Anthraquinones in Metastatic Breast ...
www.springerlink.com/index/un012m2672138624.pdf
by S Beslija - 2003 - Cited by 1 - Related articles
Key words: anthracyclines/anthraquinones, chemotherapy, metastatic breast cancer. Abstract. Anthracyclines are considered to be one of the most active agents ...

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Note added at 35 mins (2012-08-20 17:34:39 GMT)
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Síntese de pirrolonaftoquinonas derivadas do norlapachol ...
sec.sbq.org.br/cd29ra/resumos/T0215-1.pdf - Translate this page
File Format: PDF/Adobe Acrobat - Quick View
derivados contendo o núcleo 1-aza-antraquinona em um mecanismo que provavelmente envolve um intermediário imínio3. Quando os derivados nitrogenados ...

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Note added at 35 mins (2012-08-20 17:35:17 GMT)
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um novo/nova aza-antraquinona

liz askew
United Kingdom
Works in field
Native speaker of: Native in EnglishEnglish
PRO pts in category: 50
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