fed study >< fasting study

"Fast/Fed state: Clinical trial designed to investigate any differences in absorption of the drug by the body, caused by eating before the drug is given. These studies are usually run with participants being given two identical doses of the drug on different occasions; one while fasted, and one after being fed."
http://participants.algopharm.com/en/fact-or-fiction/glossar...

Reference information:
Pharmacokinetics of metformin extended release (XR) formulation were studied under fasting and fed conditions and compared to those of immediate release (IR) under fasting conditions in humans.
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Results have shown increased XR bioavailability and delayed time to reach the maximum concentration (Cmax ) in the fed state as compared to fasted state, with no significant difference in Cmax and half life values.
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The objective is to compare plasma pharmacokinetics of metformin extended release (XR) formulation studied under fasting and fed conditions and those of immediate release (IR) under fasting conditions in humans.
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In the fast studies, After 10 hr overnight fast, 1000 or 750 mg oral dose of metformin tablet was given with 240 ml water. While in the fed study dose was given directly after high fat breakfast: black olives (4 large), pita bread (3/4 of 6 inches across), 2 eggs (fried) with 3 tea spoon corn oil, 2 pieces of beef hotdog (fried) with 2 teaspoons corn oil, French fries (thin).
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Results have shown increased XR bioavailability and delayed time to reach the maximum concentration (Cmax) in the fed state as compared to fasted state, with no significant difference in Cmax and half life values.
http://www.omicsonline.org/0975-0851/JBB-03-233.php?aid=2319

"Clinical Trials for: GLIMEPIRIDE - Drug Patent Expirations - sales ...
http://www.drugpatentwatch.com/ultimate/preview/clinical.../...‎
Fasting Study of Glimepiride Tablets 1 mg to Amaryl® Tablets 1 mg, Completed, Healthy, March 31, 2008, link. The Pharmacokinetic Interaction Between ..."