English to Russian Science Biology (-tech,-chem,micro-) иммунология�

The present disclosure provides a bispecific recombinant protein and a use thereof, which can significantly enhance ***the tumor-targeting saturation binding abundance*** of a recombinant protein with an effect of modulating the function of macrophages and reduce non-tumor-target side effects.
The bispecific recombinant protein described herein can significantly enhance ***the tumor-targeting saturation binding abundance*** of a recombinant protein with an effect of modulating the function of macrophages and reduce non-tumor target side effects, as long as the ratio of the binding affinity of the antibody corresponding to the ‘high affinity tumor-targeting arm’ to the target antigen on tumor cell to the binding affinity of the homodimer of the monomer fusion protein corresponding to the ‘fusion protein with low affinity for blocking the interaction between CD47 and SIRPα to CD47’on tumor cell is at least 6.