English to Polish Medical Medical (general)

Also, repeated intrathecal injection of curcumin (50, 100, 200 mg/kg) dose-dependently attenuates glial activation and spinal neuroinflammation in a rat model of monoarthritis.

The main finding of the present study is the sustained and bilateral activation of both spinal astrocyte and microglia in response to unilateral Walker 256-injection into the tibia of rats. Moreover, the inhibition of glial activation by i.t. injection of fluorocitrate or minocycline both reduced the mechanical allodynia in rats with CIP. These findings clearly demonstrate that spinal glial activation and sustained spinal neuroinflammation contribute to the development and maintenance of allodynia in cancer induced pain. Further studies suggested that the increased spinal TLR4 expression might play an important role in the sustained glial activation we observed in our model of CIP.