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| 15:46 May 11, 2018 |
| English to Polish translations [PRO] Medical - Other | |||||||
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|  Selected response from: Frank Szmulowicz, Ph. D. United States Local time: 09:53 | ||||||
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| 2 | różnica w odporności na stres oksydacyjny między zdrowymi i nowotworymi komórkami |
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różnica w odporności na stres oksydacyjny między zdrowymi i nowotworymi komórkami Explanation: Differential refers to a difference in response, here, to the oxidative stress, between normal and cancer cells. Possibly, zróżnicowana odporność na stres oksydacyjny między zdrowymi i nowotworymi komórkami ccccccccccccc Starvation-dependent differential stress resistance protects normal but not cancer cells against high-dose chemotherapy. Here, we describe a differential stress resistance (DSR) method that focuses instead on protecting the organism but not cancer cells against chemotherapy These studies describe a starvation-based DSR strategy to enhance the efficacy of chemotherapy and suggest that specific agents among those that promote oxidative stress and DNA damage have the potential to maximize the differential toxicity to normal and cancer cells. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2448817/ cccc As previously shown by Lee et al, circulating Insulin-like growth factor 1 (IGF-1) is a key factor affected by fasting and its reduction is crucial for the establishment of Differential Stress Sensitization (DSS), a condition where cancer but not normal cell are sensitized, particularly in the presence of cytotoxic drugs(Lee et al. 2012). HO-1 is known to confer protection against oxidative damage and apoptosis Chen et al. 2004), promote tumor progression (Hirai et al. 2007; Liu et al. 2011; Metz et al. 2010) and have immuno-modulatory roles that affect various T cell subpopulations including Tregs (Brusko et al. 2005; Xia et al. 2008). Oxidative stress and the production of reactive oxygen species during chemotherapy treatment can damage normal cells, and is implicated in the toxicity of doxorubicin(Conklin 2000). http://digitallibrary.usc.edu/cdm/ref/collection/p15799coll4... |
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