Glossary entry (derived from question below)
English term or phrase:
PD-L1 axis binding antagonist
Russian translation:
антагонист, связывающийся с компонентом сигнального пути PD-L1
Added to glossary by
Tatiana Nikitina
Sep 24, 2015 17:49
9 yrs ago
1 viewer *
English term
PD-L1 axis binding antagonist
English to Russian
Science
Biology (-tech,-chem,micro-)
биохимия
Binding polypeptides are polypeptides that bind, preferably specifically, to PD-L1 as described herein. In some embodiments, the binding polypeptides are ***PD-L1 axis binding antagonist***. Binding polypeptides may be chemically synthesized using known polypeptide synthesis methodology or may be prepared and purified using recombinant technology. Binding polypeptides are usually at least about 5 amino acids in length, alternatively at least about 6, 7 or 100 amino acids in length or more, wherein such binding polypeptides that are capable of binding, preferably specifically, to a target, PD-L1, as described herein.
Спасибо
Спасибо
Proposed translations
(Russian)
| 3 | антагонист, связывающийся с компонентом сигнального пути PD-L1 |
Tatiana Nikitina
|
Change log
Sep 28, 2015 10:33: Tatiana Nikitina Created KOG entry
Proposed translations
1 hr
Tatiana Nikitina
Russian Federation
Russian Federation
Native in Russian
Specializes in field
Russian Federation
PhD, 15+ years of experience in Pharma
Native in: Russian
Works in: English to Russian, English, Russian
Related KudoZ points
:
503
Selected
антагонист, связывающийся с компонентом сигнального пути PD-L1
Насколько я поняла, слово axis иногда используют вместо pathway ("сигнальный путь"). Например: The B7-1/2/CD28 costimulatory axis is one of the most extensively studied positive signaling pathways... (http://goo.gl/gvRvGZ).
--------------------------------------------------
Note added at 1 час (2015-09-24 18:53:13 GMT)
--------------------------------------------------
Вот тут более подробно описаны эти антагонисты: The term “PD-L1 axis binding antagonist” is a molecule that inhibits the interaction of a PD-L1 axis binding partner with either one or more of its binding partner, so as to remove T-cell dysfunction resulting from signaling on the PD-1 signaling axis—with a result being to restore or enhance T-cell function. As used herein, a PD-L1 axis binding antagonist includes a PD-L1 binding antagonist and a PD-1 binding antagonist as well as molecules that interfere with the interaction between PD-L1 and PD-1 (e.g., PD-L2-Fc). [http://patents.justia.com/patent/20150071910]
--------------------------------------------------
Note added at 1 час (2015-09-24 18:53:13 GMT)
--------------------------------------------------
Вот тут более подробно описаны эти антагонисты: The term “PD-L1 axis binding antagonist” is a molecule that inhibits the interaction of a PD-L1 axis binding partner with either one or more of its binding partner, so as to remove T-cell dysfunction resulting from signaling on the PD-1 signaling axis—with a result being to restore or enhance T-cell function. As used herein, a PD-L1 axis binding antagonist includes a PD-L1 binding antagonist and a PD-1 binding antagonist as well as molecules that interfere with the interaction between PD-L1 and PD-1 (e.g., PD-L2-Fc). [http://patents.justia.com/patent/20150071910]
4 KudoZ points awarded for this answer.
Comment: "Спасибо!"
Something went wrong...