Glossary entry

English term or phrase:

Ibritumomab

Chinese translation:

替伊莫单抗

Added to glossary by ysun
May 3, 2010 17:26
14 yrs ago
English term

Ibritumomab

English to Chinese Medical Medical: Pharmaceuticals
请见 http://www.nfhoc.com/printpage.asp?ArticleID=115
根据此网页所述,“Tiuxetan为MX-DTPA螯合剂,结合Ibritumomab (另一种抗CD20单抗)后组成Ibritumomab tiuxetan(Zevalin)”。据查,Ibritumomab tiuxetan被称为替伊莫单抗。由于我的文件中将Ibritumomab 和 Ibritumomab tiuxetan分别列出,所以我的问题是Ibritumomab 在与 tiuxetan螯合剂结合之前叫什么单抗?谢谢!

Context:
Such suitable anti-tumor agents or anti-neoplastic agents include, but are not limited to, … Ibritumomab, Ibritumomab Tiuxetan, Idamycin, Idarubicin, …
Proposed translations (Chinese)
3 替伊莫单抗
3 +2 鼠源抗CD20单抗
References
FYI

Proposed translations

10 hrs
Selected

替伊莫单抗

Most search results yielded 替伊莫单抗 ==> Ibritumomab tiuxetan
although I believe to shorten it, they dropped 'tiutexan', bec. 替伊莫单抗stands for 'Ibritumomab' only.

suggestion to differentiate Ibritumomab tiuxetan from Ibritumomab (although risky):
钇90替伊莫嵌合单抗 ===> 90Y-ibritumomab tiuxetan (Zevalin)
as per ***Zevalin is a chimeric antibody radiolabeled with yttrium*** description

嵌合抗体 - chimeric antibody e.g. (Zivalin, Rituximab, Basiliximab, Infliximab, Abciximab)
ending in *** -omab *** are murine antibodies
tositumomab - is antiCD20 murine antibody just like ibritumomab


check out these translations:
西莫单抗 ==> tositumomab
利妥昔单抗 ==> rituximab
巴利昔单抗 ==> Basiliximab
英利昔单抗 ==> Infliximab
阿昔单抗 ==> Abciximab
therefore...
替伊莫单抗 ==> Ibritumomab

In Brief : Article : Nature Biotechnology This may be in part because Zevalin is a chimeric antibody radiolabeled with yttrium, whereas Bexxar is a mouse antibody using iodine: mouse antibodies are ...
www.nature.com/nbt/journal/v19/n11/full/nbt1101-1003.html - Similar



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Note added at 1 day21 hrs (2010-05-05 15:25:00 GMT)
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unconjugated ("cold") ibritumomab is what is used to call the free form of ibritumomab.

Therefore, I suggest using 非结合型 替伊莫单抗
or 冷型 替伊莫单抗 or 游离型 替伊莫单抗


Yttrium-90-Ibritumomab Tiuxetan Radioimmunotherapy: A new ... by TE WITZIG - 2004 - Cited by 14 - Related articles
In the first trial, cold ibritumomab was used prior to ibritumomab tiuxetan ... provided additional efficacy over the unconjugated ("cold") rituximab alone. ...
cat.inist.fr/?aModele=afficheN&cpsidt=15660412

非结合型单克隆抗体的抗肿瘤作用机制和影响抗体治疗的因素- 已解决- 搜 ... - [ Translate this page ]2009年12月8日 ... 治疗肿瘤用非结合型单抗依靠单抗诱导的免疫效应或单抗的直接效应杀死肿瘤细胞。单独用单抗的主要优点它们的毒副作用小、相关产物安全。
wenwen.soso.com/z/q166715387.htm - Cached

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Note added at 1 day22 hrs (2010-05-05 15:31:17 GMT)
--------------------------------------------------

more info about uncojugated and conjugated MAbs at
http://adam.about.com/reports/000084_7.htm
Something went wrong...
4 KudoZ points awarded for this answer. Comment: "非常感谢各位的帮助!参考了各位提供的信息以及其它信息,我认为 Ibritumomab 就是“替伊莫单抗”。“Ibritumomab tiuxetan”应被称为“带放射性标记的替伊莫单抗”,即Zevalin(泽娃灵或泽瓦林)。"
+2
1 hr

鼠源抗CD20单抗

鼠源抗CD20单抗
FYI
Note from asker:
Hi Cunbiao, Thank you for your help! However, I believe there are a number of murine anti-CD20 mAbs and ibritumomab is only one of them. Therefore, it might be more appropriate to specifically call it “替伊莫单抗”. What do you think? Thank you!
Peer comment(s):

agree Xiedong Lei : 带放射性标记的抗CD20单抗
6 hrs
Thanks
agree Guei Lin
1 day 18 hrs
Thanks
Something went wrong...

Reference comments

8 hrs
Reference:

FYI

Rituximab是以基因工程研制的,可变区(V区)为鼠源,其它部分和稳定区(C区)为人源的人/鼠嵌合型单克隆抗体。Rituximab与B淋巴细胞上CD20结合并引发B细胞溶解的免疫反应[8]。细胞溶解的可能机制包括补体依赖性细胞毒性(CDC)和抗体依赖性细胞的细胞毒性(ADCC)。此外,体外研究证明Rituximab可使呈药物抵抗性的人体淋巴细胞对一些化疗药物的细胞毒性敏感,并且可导致DHL-4人B淋巴细胞株凋亡。

http://www.akant.cn/leechdom/670.shtml
http://www.usnewdrug.com/Article_Show.asp?ArticleID=87&Artic...
http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=micad&par...
http://en.wikipedia.org/wiki/Ibritumomab_tiuxetan
Note from asker:
Xiedong, Thank you very much for providing these usefull links!
Something went wrong...
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