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Physicalism (which all antireductionists party to this debate embrace) assures us that whenever PS obtains, some physical process, call it Pi, obtains. Thus we can construct the identity (or at least the bi-conditional) that:

(R)PS = P1, v P2v...v Pi, v...v Pm

where m is the number, a very large number, of all the ways that macro-molecular processes can realize PS-processes.
The Protagorian theory of explanation tells us that (R) is not explanatory roughly because it's too long a sentence for people to keep in their heads. A causal theory of explanation might rule out R as explaining PS on the ground that the disjunction, P1, v P2v...v Pi, v...v Pm, is not the full cause