Доксорубицинол - основной метаболит доксорубицина.

Doxorubicinol is a major metabolite of Doxorubicin.

Doxorubucin - is an antibiotic with a broad antitumor activity that is obtained from a bacterium (Streptomyces peucetius) and is administered as the hydrochloride C27H29NO11HCl.

Doxorubicinol is highly used in drugs for AIDS patients, as well as in the following cases:

carcinoma of the breast
carcinoma of the lung
carcinoma of the ovary
transitional cell bladder cancer
neuroblastoma
Wilm's tumour
soft tissue sarcomas
osteosarcoma
acute lymphocytic - lymphoblastic leukaemia
acute myelogenous leukaemia
non-Hodgkin's lymphoma
Hodgkin's disease




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Note added at 2002-01-26 21:18:41 (GMT)
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I found a little more reference about it:

Metabolism: Doxorubicin is metabolized to a significant extent, mainly by the liver. The major metabolite of doxorubicin is 13-OH-doxorubicinol, produced by aldo-keto reductases, which possess a certain degree of antitumour activity. Doxorubicin and 13-OH-doxorubicinol predominate also in urine and in the bile. Other metabolites present in detectable amounts in plasma are the aglycones of doxorubicin and 13-OH-doxorubicinol.

Excretion: Following IV administration, plasma levels of doxorubicin follow a multiphasic decline, with a terminal half-life reported in the 20 to 48 hour range. The terminal half-life of 13-OH-doxorubicinol is similar to that of doxorubicin



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Note added at 2002-01-26 21:20:40 (GMT)
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You can read a very exhaustive article about it with all indications, dosage, administration and side effects at:
www.medsafe.govt.nz/Profs/Datasheet/a/adriamycininjpwd.htm

Адрибластин, растоцин (доксорубицин).
Международное название: Доксорубицин