Glossary entry (derived from question below)
English term or phrase:
Dose-Exposure Relationship
Russian translation:
зависимость между дозой и экспозицией
Added to glossary by
Maxim Polukhin
May 25, 2016 18:35
8 yrs ago
4 viewers *
English term
Dose-Exposure Relationship
English to Russian
Medical
Medical: Pharmaceuticals
A Semiphysiologically Based Pharmacokinetic Modeling Approach to Predict the *Dose-Exposure Relationship* of an Antiparasitic Prodrug/Active Metabolite Pair
Dose selection during antiparasitic drug development in animal models and humans traditionally has relied on correlations between plasma concentrations obtained at or below maximally tolerated doses that are efficacious. The objective of this study was to improve the understanding of the relationship between dose and plasma/tissue exposure of the model antiparasitic agent, pafuramidine, using a semiphysiologically based pharmacokinetic (semi-PBPK) modeling approach. Preclinical and clinical data generated during the development of pafuramidine, a prodrug of the active metabolite, furamidine, were used. A whole-body semi-PBPK model for rats was developed based on a whole-liver PBPK model using rat isolated perfused liver data. A whole-body semi-PBPK model for humans was developed on the basis of the whole-body rat model.
Dose selection during antiparasitic drug development in animal models and humans traditionally has relied on correlations between plasma concentrations obtained at or below maximally tolerated doses that are efficacious. The objective of this study was to improve the understanding of the relationship between dose and plasma/tissue exposure of the model antiparasitic agent, pafuramidine, using a semiphysiologically based pharmacokinetic (semi-PBPK) modeling approach. Preclinical and clinical data generated during the development of pafuramidine, a prodrug of the active metabolite, furamidine, were used. A whole-body semi-PBPK model for rats was developed based on a whole-liver PBPK model using rat isolated perfused liver data. A whole-body semi-PBPK model for humans was developed on the basis of the whole-body rat model.
Proposed translations
(Russian)
4 +2 | зависимость между дозой и экспозицией |
Leila Usmanova
![]() |
Proposed translations
+2
19 mins
Selected
зависимость между дозой и экспозицией
экспозиция - это площадь под кривой «концентрация лекарственного вещества в плазме/ткани-время» (AUC)
Поскольку в плазму/ткани поступает и находится там в неизмененном состоянии не все введенное вещество (=не вся доза), то полезно выяснить эту зависимость.
Поскольку в плазму/ткани поступает и находится там в неизмененном состоянии не все введенное вещество (=не вся доза), то полезно выяснить эту зависимость.
4 KudoZ points awarded for this answer.
Comment: "Спасибо! "
Something went wrong...