May 25, 2003 08:01
21 yrs ago
English term

cbi

English to Russian Medical folic acid deficiency in pregnancy
cbi C, D, E, F,G, methyl Cdl -

List of B12 vitamine metabolites

Proposed translations

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51 mins
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Думаю, что у вас в тексте опечатка, даже целых две. Вместо cbi и Cdl оба раза должно быть cbl.

cbl = cobalamine = vitamin B12

Five other forms of homocystinuria also reflect impaired conversion of homocysteine to methionine. The primary defects in these entities, however, are in the synthesis of methylcobalamin, a cobalamin (vitamin B12) coenzyme required by methyltetrahydrofolate:homocysteine methyltransferase (see Fig. 349.2). In some, methylmalonic acid accumulates in body fluids because of impaired synthesis of a second coenzyme, adenosylcobalamin, required for isomerization of methylmalonyl coenzyme A (CoA) to succinyl CoA. These disorders are designated cblC, -D, -E, -F, and -G.
As with 5,10-methylenetetrahydrofolate reductase deficiency, each disorder impairs remethylation of homocysteine. Since methylcobalamin is required for methyl-group transfer from methyltetrahydrofolate to homocysteine, impaired cobalamin metabolism leads to deficient methyltransferase activity. The defects responsible for impaired synthesis of methylcobalamin involve one of several steps in lysosomal or cytosolic activation of the vitamin precursor (see Fig. 349.2). In the cblF disorder, the transport of cobalamins out of lysosomes is impaired. In cblC and -D, a reductase needed for formation of both methylcobalamin and adenosylcobalamin is deficient. In cblE and -G, some component required to maintain a reduced form of cobalamin on the methyltransferase apoenzyme is impaired. Somatic cell genetic studies indicate that each of these abnormalities is distinct and imply that all are inherited as autosomal recessive traits.

cbl C, cbl D, cbl E, cbl F и cbl G --
так обозначают типы заболевания, которое называется гомоцистинурия.
Вот здесь можно посмотреть подробно: http://www.ncbi.nlm.nih.gov/htbin-post/Omim/dispmim?236200

А methyl Cdl -- это метилкобаламин.

Peer comment(s):

agree Ol_Besh
1 day 12 hrs
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4 KudoZ points awarded for this answer. Comment: "this must have been a typo or an error in OCR programme. You are as ever absolutely right!"
49 mins

кобиновая кислота; кобинамид

I. Names and Symbols

Names Symbols
corrin Crn
cobyrinic acid cobyric acid Cby
cobinic acid cobinamide Cbi
cobamic acid cobamide Cba
cobalamin Cbl

Таблица кривовата, но по ссылке нормально выглядит. :)
Ну а переводы в словаре.
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