Glossary entry (derived from question below)
German term or phrase:
präsystemische Metabolisierung
English translation:
first-pass effect/presystemic metabolization
Added to glossary by
Jonathan MacKerron
Apr 9, 2007 08:24
17 yrs ago
German term
präsystemische Metabolisierung
German to English
Medical
Medical: Pharmaceuticals
"Die absolute Bioverfügbarkeit beträgt infolge präsystemischer Metabolisierung (First-pass-Effekt) im Durchschnitt etwa 45% (mit Variationen von 20-65%). "
So is "präsystemische Metabolisierung" the same as "first-pass effect" - thanks in advance
So is "präsystemische Metabolisierung" the same as "first-pass effect" - thanks in advance
Proposed translations
(English)
4 +1 | presystemic metabolization | casper (X) |
3 +1 | presystemic metabolization | ScriptArch |
Proposed translations
+1
8 mins
Selected
presystemic metabolization
Yes. Presystemic metabolization is the same as first-pass effect.
First-pass effect: This is an extremely important phenomenon to understand. Whenever the route of administration is such that there is an organ of elimination between the administration site and the systemic circulation, there is the potential for a first-pass effect. This is sometimes referred to as presystemic elimination. The consequence of the first-pass effect is that the fraction of drug reaching the systemic circulation is substantially reduced. This explains, for example, why the dose of propranolol that is administered intravenously is so much less than that administered orally. After oral administration, all of the drug must pass through the liver before reaching the systemic circulation. This results in exposure to drug metabolizing enzymes prior to the drug reaching the systemic circulation. The intestinal wall can also represent a site of first-pass metabolism. In later lectures, we will discuss the factors that influence the first-pass metabolism of drugs.
http://www.uiowa.edu/~c046138/tut-route.htm
First-pass effect: This is an extremely important phenomenon to understand. Whenever the route of administration is such that there is an organ of elimination between the administration site and the systemic circulation, there is the potential for a first-pass effect. This is sometimes referred to as presystemic elimination. The consequence of the first-pass effect is that the fraction of drug reaching the systemic circulation is substantially reduced. This explains, for example, why the dose of propranolol that is administered intravenously is so much less than that administered orally. After oral administration, all of the drug must pass through the liver before reaching the systemic circulation. This results in exposure to drug metabolizing enzymes prior to the drug reaching the systemic circulation. The intestinal wall can also represent a site of first-pass metabolism. In later lectures, we will discuss the factors that influence the first-pass metabolism of drugs.
http://www.uiowa.edu/~c046138/tut-route.htm
Note from asker:
thanks for the confirmation |
4 KudoZ points awarded for this answer.
Comment: "thanks"
+1
8 mins
Something went wrong...