Feb 11, 2005 19:18
20 yrs ago
English term

three-class

English to Chinese Other Medical (general)
The strain of three-class antiretroviral-resistant HIV – or 3-DRC HIV – does not respond to three classes of anti-retroviral medication.

Who has time to help us find out what 3 classes refer to? IS 3-class and 3-DRC sounds like the same but what does DRC stand for?

Discussion

Non-ProZ.com Feb 11, 2005:
The client said 3-DRC= 3 drug-class-resistant. SHould be DCR if so, Right? Very likely it's a typo. I'm still checking with her.
Denyce Seow Feb 11, 2005:
Curious... how did you get "drug-class-resistant" for "DRC"????
Non-ProZ.com Feb 11, 2005:
Weiwei: 3-DRC= 3 drug-class-resistant :( ��b���I
Non-ProZ.com Feb 11, 2005:
Thanks. You great.
Denyce Seow Feb 11, 2005:
I got my answers through "research", and I am not even sure about them. Let's see what the other "medical experts" say.

Proposed translations

25 mins
Selected

NRTI, NNRTI, and PI

with three classes of drugs (NRTI, NNRTI, and PI)
- NRTI: nucleoside reverse transcriptase inhibitor
- NNRTI: non-nucleoside reverse transcriptase inhibitor
- PI: protease inhibitor

I have NOOOOOOOOOO idea what DRC is.

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Note added at 35 mins (2005-02-11 19:53:54 GMT)
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DRC = detergent-resistant complex???

We have previously identified two distinct forms of putative viral assembly intermediate complexes, a detergent-resistant complex (DRC) and a detergent-sensitive complex (DSC), in human immunodeficiency virus type 1 (HIV-1)-infected CD4+ T cells (Y. M. Lee and X. F. Yu, Virology 243:78–93, 1998).
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=11...

a detergent-resistant complex (DRC) and a detergent-sensitive complex (DSC), in human immunodeficiency virus ...
science.empas.com/search/simdoc_kisti. html?i=211961&d=A&q=%BF%AC%B7%E1%C0%FC%C1%F6

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Note added at 5 hrs 28 mins (2005-02-12 00:46:24 GMT)
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Might really be \"drug class RESISTANCE\". Check these out:

Resistance to one NNRTI leads to 抎rug class resistance
Something went wrong...
4 KudoZ points awarded for this answer. Comment: "Client changed to DCR. It was a typo. Thanks to Jianming and Lu Zou too for translating the 3 classes."
+1
20 hrs

Suggestion

在我看来原文可能有些语病,照我理解就是,“the strain”为一种病毒株, 其对3类(class)抗逆转录酶病毒的(antiretroviral)药有抗性(resistant),故对这三类药不起反应。这三类药也可能就是weiweI所提的三类。我认为“three-class antiretroviral-resistant HIV”的意思是“three-class-antiretroviral-DRUG-resistant HIV”的意思。而在文中的“or 3-DRC HIV”,意为“three-class antiretroviral-resistant HIV”即“3-DRC HIV”,故客户说DRC =3 drug-class-resistant是说得通的,虽然在文字上对不起来。HIV(人体免疫缺损病毒)是一种逆转录酶病毒(retrovirus)。
Peer comment(s):

agree Xiang Ding
1 day 12 hrs
Thanks!
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2 days 3 hrs

FYI

three-class 是如weiwei所说的三种抗HIV药物,核苷类逆转录酶抑制剂,非核苷类逆转录酶抑制剂和蛋白酶抑制剂

如果该患者对这三种药物均没有反应,说明他已经出现病毒抗药,只好进行综合性的鸡尾疗法了.
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