Jun 4, 2005 12:28
18 yrs ago
17 viewers *
English term

dummy

English Medical Medical: Pharmaceuticals
In order to keep blindness in the studies placebos matching metoprolol CR/ZOK and metoprolo CT were used in a double dumy technique

What does dummy mean here?

TIA!!!
Change log

Jun 4, 2005 12:35: Jianming Sun changed "Language pair" from "English to Chinese" to "English"

Discussion

Non-ProZ.com Jun 5, 2005:
I have found a Chinse equivalent for the term. :-)u
Non-ProZ.com Jun 5, 2005:
And, if you added that the other forms of active drug and placebo should be prepared respectively before testing, it would be easier for one to understand. :-). I have find a Chinse equivalent for the term.
Thank you all for kind help!
Non-ProZ.com Jun 5, 2005:
Thank you Elizabeth and Martinique. Elizabeth has more detailed explation!
Michael Powers (PhD) Jun 4, 2005:
Absolutely.
Non-ProZ.com Jun 4, 2005:
Thanks! I know it is also called "double blindness". What I want to know is waht "dummy" mean here?

Responses

+1
2 hrs
Selected

“blind” approach extended to the pharmaceutical form of the investigational drug


I agree with Martinique to some extent, but I feel that a clearer explanation is needed:

“Double blind” and “double dummy” are two different concepts.

Double blind = neither the investigator/research team nor the subject know whether the subject is taking the active drug or placebo.

“Double dummy” refers to the technique used, and it means that the “blind” approach is also extended to the pharmaceutical form of the investigational drug, as defined below:

Double dummy refers to a procedure that is used when the two treatments are so obviously different that it would undermine the whole double blind idea.
For instance, you want to test a medication that is in capsule form to a medication that is a liquid. Obviously, the subject would know what they were getting if just given one of the medications. So each subject receives both treatments with groups structured as follows:
Group One: active capsule, placebo liquid
Group Two: placebo capsule, active liquid
Group Three: placebo capsule, placebo liquid.
http://www.pballew.net/arithme2.html

Double Dummy: A technique for retaining the blind when administering supplies in a clinical trial, when the two treatments cannot be made identical. Supplies are prepared for Treatment A (active and indistinguishable placebo) and for Treatment B (active and indistinguishable placebo). Subjects then take two sets of treatment; either A (active) and B (placebo) or A (placebo) and B (active). http://www.actmagazine.com/appliedclinicaltrials/article/art...

Hope this helps.


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Note added at 3 hrs 4 mins (2005-06-04 15:33:01 GMT)
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I have three suggestions:
1. Try to find out whether there is an accepted and widely used Chinese equivalent for this clinical study term.
2. Leave “double dummy” in English (can you do this in a Chinese text?:))– medical professionals will probably understand the concept. To be on the safe side, you can insert the explanation in Chinese in brackets.
3. Use an acceptable Chinese term for “dummy”, but if this hasn’t been used before in this context, I would still insert the explanation in Chinese and/or \"double dummy\" in English in brackets.
You could perhaps translate it as \"double placebo\", as defined below:
double placebo - A placebo having two different shapes or forms, eg, a tablet and a capsule, as needed in a double placebo treatment design; also double dummy placebo. rt: single placebo, multiple placebo.
http://www.jhucct.com/clm/gppps/Mak.pdf

Peer comment(s):

agree Martinique : Well put :)
20 hrs
Thank you!
Something went wrong...
4 KudoZ points awarded for this answer.
+1
8 mins

not knowing if it is the placebo or the medication

Mike :)

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Note added at 10 mins (2005-06-04 12:38:32 GMT)
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This is the technique in which neither the people in the group that receives the medication nor those in the control group is aware that they are actually taking the medication or the placebo. This inhibits the so-called placebo effect, and gives more realistic results.

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Note added at 12 mins (2005-06-04 12:40:30 GMT)
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Cochrane Infectious Diseases Gro
... placebo or a double dummy technique such that neither the participant or care
... (3) Outcomes. Treatment failure (unadjusted). Time point:. Definition: ...
www.liv.ac.uk/lstm/ehcap/CIDG/methods-guide.htm - 114k - Cached - Similar pages



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Note added at 12 mins (2005-06-04 12:41:04 GMT)
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Quite often the double dummy technique is used when two different interventions for the same potential treatment are being tested.

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Note added at 13 mins (2005-06-04 12:41:38 GMT)
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[PDF] Drugs Aging 2003; 20 (11): 847-855
File Format: PDF/Adobe Acrobat
definition included chorea, dystonia, myoclonus or. mum of 600mg per day in
divided doses ... of the double-dummy technique. Patients were al-. (figure 1). ...
www.ingentaconnect.com/content/ adis/dag/2003/00000020/00000011/art00006 - Similar pages

Journal of Cardiovascular Pharmacology - Fulltext: Volume 28(1 ...
... treatment with the active compounds administered with a double-dummy technique.
... sounds (phase V) was used for the definition of diastolic BP (DBP). ...
www.cardiovascularpharm.com/pt/re/ jcardiopharm/fulltext.00005344-199607000-00001.htm - Similar pages

Journal of Cardiovascular Pharmacology - Fulltext: Volume 29(4 ...
The double-dummy technique was applied because the formulation of both active
drugs was not identical. ... as well as by definition of ischemia end points. ...
www.cardiovascularpharm.com/pt/re/ jcardiopharm/fulltext.00005344-199704000-00014.htm - Similar pages

Randomised Controlled Trials
The double dummy technique is particularly useful when the investigators want to
compare interventions that are administered by different routes or that ...
www.cgmh.org.tw/intr/intr5/c6700/ OBGYN/F/Randomized%20tial/chapter2.html - 66k - Cached - Similar pages

Peer comment(s):

agree Xuchun
5 mins
Thank you, Xuchum - Mike :)
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+2
24 mins

Double blind

This is the usual term for a study where neither the researcher nor the person receiving the medicine or treatment knows which is the placebo, so they don't influence the results. Lots of Googles.
Peer comment(s):

agree Nick Lingris : Yes, indeed! Especially in British studies this is the usual term.
24 mins
agree humbird : Yes "double blind". It is most common in this context. I never heard "double dummy".
12 hrs
Something went wrong...
25 mins

simulation

double simulation
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+1
1 hr

dummy = placebo; double-dummy = two placebos

"double-blind" is not equal to "double-dummy"

http://www.nap.edu/books/0309073332/html/32.html
...Two drugs may have different forms (e.g., an intravenously administered form versus a tablet form) that cannot be changed without changing the properties of the drugs. One way to design a double-blind trial in this instance is to use a ***double-dummy technique (e.g., the use of *two placebos* to disguise which drug the participants are receiving)***.

More:
Double-dummy. It is often impossible to match two active drugs (e.g. a tablet and a syrup). In this situation, ***placebos matching both active drugs are formulated***. The treatment groups become:
Active A + Placebo B vs. Active B + Placebo A.
This results in greater packing, administrative and formulation expense. It also requires a greater degree of comprehension and cooperation by the patient.

HTH
Peer comment(s):

agree Mihaela Brooks
12 hrs
Thank you :)
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