Mar 19, 2008 11:51
16 yrs ago
English term
Verona clinical evaluation
English to Italian
Medical
Medical (general)
Titolo della sperimentazione clinica di cui ho parlato nell'altra domanda: The Verona Clinical Evaluation of Adipose Derived Regenerative Cells in the Treatment of Patients...
La città di Verona non ha alcuna attinenza con la sperimentazione di cui si parla, ma non riesco a trovare nessun altro riferimento online. Qualche idea? Grazie
La città di Verona non ha alcuna attinenza con la sperimentazione di cui si parla, ma non riesco a trovare nessun altro riferimento online. Qualche idea? Grazie
Proposed translations
(Italian)
| 4 +2 | studio clinico effettuato a Verona/veronese |
Zea_Mays
|
| 3 +2 | ho trovato questo |
Laura Gentili
|
| 3 | non può essere un cognome? |
Monia Di Martino
|
Proposed translations
+2
2 hrs
Selected
studio clinico effettuato a Verona/veronese
Cit.: "Presentati i risultati di uno studio in cui cellule staminali derivanti da tessuto adiposo e cellule rigenerative sono state utilizzate per la ricostruzione del seno dopo mastectomia parziale"
http://www.molecularlab.it/news/view.asp?n=5757
"Clinical Evaluation of Adipose Derived Regenerative Cells"
"studi clinici su cellule rigenerative derivanti da tessuto adiposo"
Una pagina in inglese che riporta il testo originale:
"Official Title: A Clinical Evaluation of Adipose Derived Regenerative Cells in the Treatment of Patients With Breast Deformities Post-Segmental Breast Resection"
http://clinicaltrials.gov/ct2/show?term=Mammaplasty&recr=ope...
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Note added at 2 Stunden (2008-03-19 14:24:01 GMT)
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Non si trovano riferimenti diretti a Verona - nel caso di studi recenti sarebbe un aspetto comprensibile.
A meno che non sia prassi intitolare una ricerca. O che si tratti effettivamente del nome di un ricercatore.
Si trova un "Dipartimento di Scienze Morfologico-Biomediche, University of Verona, Strada Le Grazie 8, 37134, Verona, Italy."
http://www.molecularlab.it/news/view.asp?n=5757
"Clinical Evaluation of Adipose Derived Regenerative Cells"
"studi clinici su cellule rigenerative derivanti da tessuto adiposo"
Una pagina in inglese che riporta il testo originale:
"Official Title: A Clinical Evaluation of Adipose Derived Regenerative Cells in the Treatment of Patients With Breast Deformities Post-Segmental Breast Resection"
http://clinicaltrials.gov/ct2/show?term=Mammaplasty&recr=ope...
--------------------------------------------------
Note added at 2 Stunden (2008-03-19 14:24:01 GMT)
--------------------------------------------------
Non si trovano riferimenti diretti a Verona - nel caso di studi recenti sarebbe un aspetto comprensibile.
A meno che non sia prassi intitolare una ricerca. O che si tratti effettivamente del nome di un ricercatore.
Si trova un "Dipartimento di Scienze Morfologico-Biomediche, University of Verona, Strada Le Grazie 8, 37134, Verona, Italy."
Peer comment(s):
| agree |
Rita Bilancio
: era quello a cui avevo effettivamente pensato anche io, ci sono varie entry sui motori di ricerca
9 mins
|
|
;-) Per la mancanza di riferimenti diretti, un margine di dubbio rimane.
|
|
| agree |
Serena Fermo
2 days 10 hrs
|
4 KudoZ points awarded for this answer.
Comment: "Grazie, anche per i riferimenti. Ho chiesto comunque notizie al cliente, che risponderà dopo Pasqua, ma per ora tengo buona questa risposta"
12 mins
Monia Di Martino
Italy
Italy
Native in Italian
Specializes in field
Italy
Accuracy and reliability
Native in: Italian 
Works in: English to Italian, Spanish to Italian, Italian to English
Related KudoZ points
:
77
+2
9 mins
Laura Gentili
Italy
Italy
Native in Italian
Specializes in field
Italy
problem solving, proactive approach
Native in: Italian 
Works in: English to Italian, Hebrew to Italian
Related KudoZ points
:
739
ho trovato questo
Non hai dato molto contesto.
ho trovato questo:
Plast Reconstr Surg. 2007 Apr 15;119 (5):1409-22; discussion 1423-4 17415234 (P,S,E,B,D)
Clinical treatment of radiotherapy tissue damage by lipoaspirate transplant: a healing process mediated by adipose-derived adult stem cells.
Gino Rigotti, Alessandra Marchi, Mirco Galiè, Guido Baroni, Donatella Benati, Mauro Krampera, Annalisa Pasini, Andrea Sbarbati
Second Division of Plastic and Reconstructive Surgery, the Institute for Burns, and Regional Center for Breast Reconstruction, Ospedale Maggiore di Verona, Verona, Italy. [email protected]
BACKGROUND: There is evidence that stem cells contribute to the restoration of tissue vascularization and organ function. The objective of this study was to assess the presence of adipose-derived adult stem cells left in their natural scaffold in the purified lipoaspirate and to assess the clinical effectiveness of lipoaspirate transplantation in the treatment of radiation side effects. METHODS: This study was designed beginning with surgical procedures in 2002 and envisaging a continuous patient follow-up to 31 months. Twenty consecutive patients undergoing therapy for side effects of radiation treatment with severe symptoms or irreversible function damage (LENT-SOMA scale grade 3 and 4) were enrolled. Purified autologous lipoaspirates (60 to 120 cc) taken from a healthy donor site were administered by repeated low-invasive computer-assisted injection. Therapy outcomes were assessed by symptoms classification according to the LENT-SOMA scale, cytofluorimetric characterization, and ultrastructural evaluation of targeted tissue. RESULTS: In the isolated stromal vascular fraction of 2 cc of human lipoaspirate, cells with mesenchymal stem cell physical properties and immunophenotype were in average 1.07 +/- 0.5 percent (n = 4), with a clonogenic fraction of 0.139 percent. At least 1.02 x 10(3) colony-forming units-fibroblast were present in each lipoaspirate. Ultrastructure of target tissue systematically exhibited progressive regeneration, including neovessel formation and improved hydration. Clinical outcomes led to a systematic improvement or remission of symptoms in all evaluated patients, including otherwise untreatable patients exhibiting initial irreversible functional damage. CONCLUSIONS: This surgical procedure is a low-invasive therapeutic approach for resolving the late side effects of radiotherapy. According to the proposed hypothesis of the ischemic nature of radiolesions, treatment with lipoaspirate transplantation is potentially extended to other forms of microangiopathies.
--------------------------------------------------
Note added at 3 hrs (2008-03-19 15:05:18 GMT)
--------------------------------------------------
A me sembra un tipico caso in cui occorre chiedere al cliente
ho trovato questo:
Plast Reconstr Surg. 2007 Apr 15;119 (5):1409-22; discussion 1423-4 17415234 (P,S,E,B,D)
Clinical treatment of radiotherapy tissue damage by lipoaspirate transplant: a healing process mediated by adipose-derived adult stem cells.
Gino Rigotti, Alessandra Marchi, Mirco Galiè, Guido Baroni, Donatella Benati, Mauro Krampera, Annalisa Pasini, Andrea Sbarbati
Second Division of Plastic and Reconstructive Surgery, the Institute for Burns, and Regional Center for Breast Reconstruction, Ospedale Maggiore di Verona, Verona, Italy. [email protected]
BACKGROUND: There is evidence that stem cells contribute to the restoration of tissue vascularization and organ function. The objective of this study was to assess the presence of adipose-derived adult stem cells left in their natural scaffold in the purified lipoaspirate and to assess the clinical effectiveness of lipoaspirate transplantation in the treatment of radiation side effects. METHODS: This study was designed beginning with surgical procedures in 2002 and envisaging a continuous patient follow-up to 31 months. Twenty consecutive patients undergoing therapy for side effects of radiation treatment with severe symptoms or irreversible function damage (LENT-SOMA scale grade 3 and 4) were enrolled. Purified autologous lipoaspirates (60 to 120 cc) taken from a healthy donor site were administered by repeated low-invasive computer-assisted injection. Therapy outcomes were assessed by symptoms classification according to the LENT-SOMA scale, cytofluorimetric characterization, and ultrastructural evaluation of targeted tissue. RESULTS: In the isolated stromal vascular fraction of 2 cc of human lipoaspirate, cells with mesenchymal stem cell physical properties and immunophenotype were in average 1.07 +/- 0.5 percent (n = 4), with a clonogenic fraction of 0.139 percent. At least 1.02 x 10(3) colony-forming units-fibroblast were present in each lipoaspirate. Ultrastructure of target tissue systematically exhibited progressive regeneration, including neovessel formation and improved hydration. Clinical outcomes led to a systematic improvement or remission of symptoms in all evaluated patients, including otherwise untreatable patients exhibiting initial irreversible functional damage. CONCLUSIONS: This surgical procedure is a low-invasive therapeutic approach for resolving the late side effects of radiotherapy. According to the proposed hypothesis of the ischemic nature of radiolesions, treatment with lipoaspirate transplantation is potentially extended to other forms of microangiopathies.
--------------------------------------------------
Note added at 3 hrs (2008-03-19 15:05:18 GMT)
--------------------------------------------------
A me sembra un tipico caso in cui occorre chiedere al cliente
Peer comment(s):
| agree |
texjax DDS PhD
: concordo sul tipico caso, in questa circostanza. Buona giornata!
3 hrs
|
| agree |
Zea_Mays
: agree, indispensabile chiedere.
20 hrs
|
Discussion
Quanto al cognome potrenne anche essere ma non ho trovato alcun riferimento in proposito...