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English英语译成Korean韩语: Animal Models and Cell Cultures Detailed field: 医疗：医疗服务
原文文本 - English英语 Animal Models and Cell Cultures
For evaluating the potential of vaccines and therapeutics against Co Vs, including SARS-Co V, MERS-Co Vs, and the presently emerging SARS-CoV-2, suitable animal models that can mimic the clinical disease are needed (211, 212). Various animal models were assessed for SARS-and MERS-Co Vs, such as mice, guinea pigs, golden Syrian hamsters, ferrets, rabbits, and nonhuman primates like rhesus macaques, marmosets, and cats (185, 213- 218). The specificity of the virus to hACE2 (receptor of SARS-CoV) was found to be a significant barrier in developing animal models. Consequently, a SARS-CoV transgenic mouse model has been developed by inserting the hACE2 gene into the mouse genome (219). The inability of MERS-Co V to replicate in the respiratory tracts of animals (mice, hamsters, and ferrets) is another limiting factor. However, with genetic engineering, a 288-330+/+ MERS-Co V genetically modified mouse model was developed and now is in use for the assessment of novel drugs and vaccines against MERS-Co V (220). In the past, small animals (mice or hamsters) have been targeted for being closer to a humanized structure, such as mouse DPP4 (hDPP4), hDPP4-transduced mice, and hDPP4-Tg (transgenic for expressing
翻译文本 - Korean韩语 동물 모델 및 세포 배양
SARS-Co V, MERS-Co Vs 및 현재 부상하고 있는 SARS-CoV-2를 포함한 Co Vs에 대한 백신 및 치료제의 잠재력을 평가하기 위해서는 임상 질병을 모방할 수 있는 적합한 동물 모델이 필요합니다(211, 212). 쥐, 기니피그, 황금 시리아 햄스터, 흰 족제비, 토끼 및 붉은털 원숭이, 마모셋, 고양이와 같은 비인간 영장류와 같은 SARS-및 MERS-Co V에 대해 다양한 동물 모델을 평가했습니다(185, 213-218). hACE2 (SARS-CoV의 수용체)에 대한 바이러스의 특이성은 동물 모델 개발에 중요한 장벽으로 밝혀졌습니다. 결과적으로, hACE2 유전자를 마우스 게놈에 삽입함으로써 SARS-CoV 형질전환 마우스 모델이 개발되었다(219). MERS-Co V가 동물 (마우스, 햄스터 및 흰 족제비)의 호흡기에서 복제 할 수 없다는 것은 또 다른 제한 요소입니다. 그러나 유전 공학을 통해 288-330+/+ MERS-CoV 유전자 변형 마우스 모델이 개발되었으며 현재 MERS-Co V(220)에 대한 신약 및 백신의 평가에 사용되고 있습니다. 과거에는 작은 동물 (마우스 또는 햄스터)이 인간화 구조에 더 가까운 것으로 표적화되었습니다., 예를 들어 마우스 DPP4 (hDPP4), hDPP4 형질 도입 마우스 및 hDPP4-Tg (발현을 위해 형질 전환
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I love to watch Korean movies and dramas, that's why I studied the Korean language. How to write and read. I have also been to Japan a few years ago. I love to travel to different countries to see their culture, food, and hobbies. I've been in Customer Service for more than 5 years and 11 months. I do copywriting and translation jobs too. I have my own Youtube channel too.
