Glossary entry (derived from question below)
Deutsch term or phrase:
auf die Base umrechnen
Englisch translation:
calculated as the free base
Added to glossary by
Asya Sokirko
Dec 19, 2022 20:37
1 yr ago
33 viewers *
Deutsch term
auf die Base umrechnen
Deutsch > Englisch
Naturwissenschaften
Chemie, -technik
Pharmacology
The amount of a certain substance is stated "entsprechend der auf die Base umgerechneten Menge" of one of its components. If I could at least figure out what it is, I could probably find the term. Thanks in advance everybody!
Proposed translations
(Englisch)
Proposed translations
+3
1 Stunde
Selected
calculated as the free base
The certain sentence is probably a salt (e.g. pyridine hydrochloride) and the quantity (mass = Menge) of it is provided as the equivalent mass of the free base (e.g. pyridine).
See the example sentence, which is claim #1 in the patent linked as a reference.
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Note added at 1 hr (2022-12-19 21:50:52 GMT)
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Sorry for the typo, certain sentence should be certain substance. :)
See the example sentence, which is claim #1 in the patent linked as a reference.
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Note added at 1 hr (2022-12-19 21:50:52 GMT)
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Sorry for the typo, certain sentence should be certain substance. :)
Example sentence:
Pharmaceutical composition comprising ... or a pharmaceutically acceptable salt thereof wherein a unit dose of the composition contains 1200 to 1300 mg of the active pharmaceutical ingredient calculated as the free base.
Peer comment(s):
agree |
TonyTK
: Not my field, but this certainly makes sense.
9 Stunden
|
agree |
Cillie Swart
: seems plausible, thanks for sharing
9 Stunden
|
agree |
Kim Metzger
14 Stunden
|
4 KudoZ points awarded for this answer.
Comment: "Thanks a lot!"
-1
47 Min.
volume adjusted in proportion to the base
you will need a particular acid:base ratio to make the reaction proceed as required
something like this https://www.omnicalculator.com/chemistry/henderson-hasselbal...
something like this https://www.omnicalculator.com/chemistry/henderson-hasselbal...
Peer comment(s):
disagree |
Róbert Hanczkó, Ph.D.
: This is a total miss. Sorry. We are talking about some sort of substance which is probably in the form of a salt, thus we cannot talk about volumes but mass (see Menge) as in grams if anything.
12 Min.
|
-2
48 Min.
in the converted base
What do you mean by base conversion?
Changing numeral bases, such as converting from base 2 (binary) to base 10 (decimal). - https://en.wikipedia.org/wiki/Change_of_base
a base is a substance which dissociates in aqueous solution to form Hydroxide ions OH−. - https://en.wikipedia.org/wiki/Base_(chemistry)
System of Units (SI).
Amount nX is an elementary quantity, converting the elementary unit [x] into the SI base unit mole [mol] using the Avogadro constant NA. - https://www.bioblast.at/index.php/Amount_of_substance
The SI unit of concentration (of amount of substance) is the mole per cubic meter (mol/m3). - https://www.nist.gov/pml/owm/si-units-amount-substance
Stoffmenge f (genitive Stoffmenge, plural Stoffmengen). - (chemistry) mole (amount of substance). - https://www.dict.cc/?s=Stoffmenge
converted amount of substance base
in British English
NOUN
a measure of the number of entities (atoms, molecules, ions, electrons, etc) present in a substance, expressed in moles - https://www.collinsdictionary.com/dictionary/english/amount-...
Changing numeral bases, such as converting from base 2 (binary) to base 10 (decimal). - https://en.wikipedia.org/wiki/Change_of_base
a base is a substance which dissociates in aqueous solution to form Hydroxide ions OH−. - https://en.wikipedia.org/wiki/Base_(chemistry)
System of Units (SI).
Amount nX is an elementary quantity, converting the elementary unit [x] into the SI base unit mole [mol] using the Avogadro constant NA. - https://www.bioblast.at/index.php/Amount_of_substance
The SI unit of concentration (of amount of substance) is the mole per cubic meter (mol/m3). - https://www.nist.gov/pml/owm/si-units-amount-substance
Stoffmenge f (genitive Stoffmenge, plural Stoffmengen). - (chemistry) mole (amount of substance). - https://www.dict.cc/?s=Stoffmenge
converted amount of substance base
in British English
NOUN
a measure of the number of entities (atoms, molecules, ions, electrons, etc) present in a substance, expressed in moles - https://www.collinsdictionary.com/dictionary/english/amount-...
Peer comment(s):
disagree |
Róbert Hanczkó, Ph.D.
: This is a total miss. Sorry. The base is not converted into anything it is a form of the substance.
8 Min.
|
What do you mean by base conversion? Changing numeral bases, such as converting from base 2 (binary) to base 10 (decimal). - https://en.wikipedia.org/wiki/Change_of_base
|
|
disagree |
Cilian O'Tuama
: It's about acid/base - better you stick to dubious references
4 Tage
|
-1
10 Stunden
as per the quantity adjusted for the new base
I think they're saying you need to like adjust the quantities based on whatever the (new) base may be. Think of it like a recipe. On the package it says how to make it for 4 people, but if you make it for 2 people, you need to half all the ingredients. So your new base in this case would be 2 people. But in this case the "base", is also a dependent variable, which is why it says umgerechnet. So there is some calculation, the answer of which determines the "base". And then the quantity (Menge) that this phrase is talking about will presumably be some function (multiple or whatever (or calculation in this case better word)) of that (new) base.
I wouldn't want to use the etymology of base twice, so unless you can use a different word for the German "Base" here like "baseline amount" or something I would probably go for something like:
according to / as per (entsprechend) the base-adjusted quantity
OR a little more wordy:
as per the new quantity calculated given the new baseline / base
OR perhaps most elegantly:
according to the new quantity / amount / volume adjusted for the base / baseline
I wouldn't want to use the etymology of base twice, so unless you can use a different word for the German "Base" here like "baseline amount" or something I would probably go for something like:
according to / as per (entsprechend) the base-adjusted quantity
OR a little more wordy:
as per the new quantity calculated given the new baseline / base
OR perhaps most elegantly:
according to the new quantity / amount / volume adjusted for the base / baseline
Peer comment(s):
disagree |
Róbert Hanczkó, Ph.D.
: This is a total miss too. Sorry. There is no "new" base, just a singe 1. It is not a recipe, it is about a molecule that is either a salt or a free base. Also, this is a professional text, it is OK to use base more times if this is the correct term.
1 Stunde
|
Thank you for the feedback! Greatly appreciated...
|
-1
13 Stunden
Deutsch term (edited):
auf die Base umgerechneten Menge
as a ratio of the quantity converted to the base
Zunächst einige Erklärungen:
Die unedelsten Metalle (oft ebenfalls Basenbildner genannt) bilden die stärksten Basen, d. h. diese unterliegen bei der Auflösung in Wasser vollständiger elektrolytischer Dissoziation in die Metallkationen und Hydroxid-Ionen.
Zu den starken Basen gehören Kalilauge, Natronlauge, Barium-, Calcium- und Strontiumhydroxid, zu den mittelstarken Silberoxid (bildet mit Wasser ein – allerdings nicht rein herstellbares – Hydroxid, AgOH), zu den schwachen dagegen Ammoniumhydroxid, Magnesiumhydroxid usw.
:
Einwertige Basen können mit einwertigen Säuren nur neutrale, mehrwertige Basen dagegen auch basische Salze bilden, wenn die Neutralisation unvollständig ist. Neutralisations-, Protolyse- und Pufferungsvorgänge spielen sich ständig im lebenden Organismus ab, siehe Säure-Basen-Gleichgewicht…
:
Einwertige Basen können mit einwertigen Säuren nur neutrale, mehrwertige Basen dagegen auch basische Salze bilden, wenn die Neutralisation unvollständig ist.
:
Übersetzungen:
E bases
F bases
I basi
S bases
https://roempp.thieme.de/lexicon/RD-02-00317?searchterm=base...
Bei der Neutralisation reagiert eine Base mit einer Säure zu einem Salz und Wasser. Die Bestandteile in der Säure (Oxonium-Ionen) und der Base (Hydroxid-Ionen), die ihre sauren bzw. alkalischen Eigenschaften ausmachen, reagieren miteinander zu Wasser.
https://de.wikipedia.org/wiki/Salzbildungsreaktion
Die Stöchiometrie (von gr. στοιχεῖον stoicheion „Grundstoff“ und μέτρον metron „Maß“) ist ein grundlegendes mathematisches Hilfsmittel in der Chemie. Mit ihrer Hilfe werden aus der qualitativen Kenntnis der Reaktanten und Produkte einer Reaktion die tatsächlichen Mengenverhältnisse (Reaktionsgleichung) und Stoffmengen berechnet. In der chemischen Umgangssprache bezeichnet Stöchiometrie nicht die (meist triviale) Berechnung, sondern deren Ergebnis.
https://de.wikipedia.org/wiki/Stöchiometrie
Stoichiometry is not only used to balance chemical equations but also used in conversions, i.e., converting from grams to moles using molar mass as the conversion factor, or from grams to milliliters using density. For example, to find the amount of NaCl (sodium chloride) in 2.00 g, one would do the following:
[formule] = 0.0342 mol
In the above example, when written out in fraction form, the units of grams form a multiplicative identity, which is equivalent to one (g/g = 1), with the resulting amount in moles (the unit that was needed), as shown in the following equation
:
The following steps would be used:
1. Write and balance the equation
2. Mass to moles: Convert grams of Cu to moles of Cu
3. Mole ratio: Convert moles of Cu to moles of Ag produced
4. Mole to mass: Convert moles of Ag to grams of Ag produced
https://en.wikipedia.org/wiki/Stoichiometry
chemical equation is the symbolic representation of a chemical reaction in the form of symbols and chemical formulas. The reactant entities are given on the left-hand side and the product entities on the right-hand side with a plus sign between the entities in both the reactants and the products, and an arrow that points towards the products to show the direction of the reaction.[1] The chemical formulas may be symbolic, structural (pictorial diagrams), or intermixed. The coefficients next to the symbols and formulas of entities are the absolute values of the stoichiometric numbers.
https://en.wikipedia.org/wiki/Chemical_equation
Now to the question (expressed in German und improved):
"Die Menge einer bestimmten Substanz wird im Verhältnis zu der in die Basis umgerechneten Menge angegeben".
=>
"The quantity of a given substance is expressed as a ratio of the quantity converted to the base".
The quantity unit is secondary for this question, it is usually given in mol or gram.
Die unedelsten Metalle (oft ebenfalls Basenbildner genannt) bilden die stärksten Basen, d. h. diese unterliegen bei der Auflösung in Wasser vollständiger elektrolytischer Dissoziation in die Metallkationen und Hydroxid-Ionen.
Zu den starken Basen gehören Kalilauge, Natronlauge, Barium-, Calcium- und Strontiumhydroxid, zu den mittelstarken Silberoxid (bildet mit Wasser ein – allerdings nicht rein herstellbares – Hydroxid, AgOH), zu den schwachen dagegen Ammoniumhydroxid, Magnesiumhydroxid usw.
:
Einwertige Basen können mit einwertigen Säuren nur neutrale, mehrwertige Basen dagegen auch basische Salze bilden, wenn die Neutralisation unvollständig ist. Neutralisations-, Protolyse- und Pufferungsvorgänge spielen sich ständig im lebenden Organismus ab, siehe Säure-Basen-Gleichgewicht…
:
Einwertige Basen können mit einwertigen Säuren nur neutrale, mehrwertige Basen dagegen auch basische Salze bilden, wenn die Neutralisation unvollständig ist.
:
Übersetzungen:
E bases
F bases
I basi
S bases
https://roempp.thieme.de/lexicon/RD-02-00317?searchterm=base...
Bei der Neutralisation reagiert eine Base mit einer Säure zu einem Salz und Wasser. Die Bestandteile in der Säure (Oxonium-Ionen) und der Base (Hydroxid-Ionen), die ihre sauren bzw. alkalischen Eigenschaften ausmachen, reagieren miteinander zu Wasser.
https://de.wikipedia.org/wiki/Salzbildungsreaktion
Die Stöchiometrie (von gr. στοιχεῖον stoicheion „Grundstoff“ und μέτρον metron „Maß“) ist ein grundlegendes mathematisches Hilfsmittel in der Chemie. Mit ihrer Hilfe werden aus der qualitativen Kenntnis der Reaktanten und Produkte einer Reaktion die tatsächlichen Mengenverhältnisse (Reaktionsgleichung) und Stoffmengen berechnet. In der chemischen Umgangssprache bezeichnet Stöchiometrie nicht die (meist triviale) Berechnung, sondern deren Ergebnis.
https://de.wikipedia.org/wiki/Stöchiometrie
Stoichiometry is not only used to balance chemical equations but also used in conversions, i.e., converting from grams to moles using molar mass as the conversion factor, or from grams to milliliters using density. For example, to find the amount of NaCl (sodium chloride) in 2.00 g, one would do the following:
[formule] = 0.0342 mol
In the above example, when written out in fraction form, the units of grams form a multiplicative identity, which is equivalent to one (g/g = 1), with the resulting amount in moles (the unit that was needed), as shown in the following equation
:
The following steps would be used:
1. Write and balance the equation
2. Mass to moles: Convert grams of Cu to moles of Cu
3. Mole ratio: Convert moles of Cu to moles of Ag produced
4. Mole to mass: Convert moles of Ag to grams of Ag produced
https://en.wikipedia.org/wiki/Stoichiometry
chemical equation is the symbolic representation of a chemical reaction in the form of symbols and chemical formulas. The reactant entities are given on the left-hand side and the product entities on the right-hand side with a plus sign between the entities in both the reactants and the products, and an arrow that points towards the products to show the direction of the reaction.[1] The chemical formulas may be symbolic, structural (pictorial diagrams), or intermixed. The coefficients next to the symbols and formulas of entities are the absolute values of the stoichiometric numbers.
https://en.wikipedia.org/wiki/Chemical_equation
Now to the question (expressed in German und improved):
"Die Menge einer bestimmten Substanz wird im Verhältnis zu der in die Basis umgerechneten Menge angegeben".
=>
"The quantity of a given substance is expressed as a ratio of the quantity converted to the base".
The quantity unit is secondary for this question, it is usually given in mol or gram.
Peer comment(s):
disagree |
Róbert Hanczkó, Ph.D.
: No ratio is mentioned. This is an absolute (weight?) value and not a ratio.
4 Tage
|
Selbstverständlich ist "entsprechend der auf die Base umgerechneten Menge" ein Verhältnis (auf Englisch "ratio")
|
15 Stunden
base equivalent
(Or free base equivalent)
I assume they did some sort of titration to figure out the amount of the compound.
For example, they titrated it with NaOH. They recorded how much NaOH was needed to reach the endpoint and then used this to calculate the amount of the compound of interest.
[0070] For administration of pharmaceutically acceptable salts of the above compounds, the weights indicated above refer to the weight of the acid equivalent or the base equivalent of the therapeutic compound derived from the salt.
https://data.epo.org/publication-server/document?iDocId=3129...
Discussion
For example, what is the purpose of this chemical process and the final product? Can you also indicate the name(s) of base(s) and acidic radicals?